PMID: 11929115Apr 4, 2002Paper

Caffeine ameliorates radiation-induced skin reactions in mice but does not influence tumour radiation response

Journal of Radiological Protection : Official Journal of the Society for Radiological Protection
S A HebbarN C Verma

Abstract

Intramuscular administration of caffeine at a dose of 80 mg kg(-1) body weight to the gastrocnemius muscles of Swiss mice 5 min prior to local irradiation (35 Gy) of the leg delayed the progression of radiation-induced skin reactions in such animals. While 90% epilation with reddening of the skin was noted in animals treated with radiation alone, animals pretreated with caffeine suffered only partial hair loss with slight reddening of the skin on the 16th and 20th days post-irradiation. Beyond the 28th day, damage scores in irradiated feet for both the groups were similar (score 3) and remained unchanged until the 32nd day and then decreased and disappeared completely in both treatment groups by the 40th day after irradiation. In addition, the effect of caffeine on the radiation response of a mouse fibrosarcoma was investigated. Results showed that intratumoral administration of caffeine at a dose of 80 mg kg(-1) body weight 5 min prior to local exposure of tumours to 10 Gy of 60Co gamma-rays did not influence the response of tumours to radiation. The present study thus showed that although caffeine ameliorated radiation-induced skin reactions in the mouse leg, it did not affect the tumour radiation response, indicating its pot...Continue Reading

References

Aug 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M W DionB Anderson
Aug 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P C Kesavan, E L Powers
Dec 1, 1973·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P C KesavanA Ahmad
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J O ArchambeauT Wasserman
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·K J StelzerT W Griffin
Jun 13, 1996·Biochimica Et Biophysica Acta·T P DevasagayamP C Kesavan
Jul 10, 1999·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·K C GeorgeP C Kesavan

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Citations

Jun 25, 2003·Toxicology·Joseph F Weiss, Michael R Landauer
Jun 27, 2009·International Journal of Radiation Biology·Joseph F Weiss, Michael R Landauer
Jan 26, 2016·Medicinal Research Reviews·Mohammad Zahid KamranVibha Tandon
Mar 1, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·S B TekinS Altas
Jan 4, 2012·Clinical and Experimental Dermatology·E YirmibesogluS Omeroglu
Oct 7, 2004·International Journal of Radiation Oncology, Biology, Physics·Brian D LawendaJay S Loeffler
Jan 19, 2012·Journal of Plastic Surgery and Hand Surgery·Megumi TakikawaTomoharu Kiyosawa
Aug 4, 2016·Journal of Dietary Supplements·Andrés Uc CachónRosa E Moo-Puc
Jul 12, 2016·Antioxidants·Susan HallShailendra Anoopkumar-Dukie
Apr 7, 2018·Critical Reviews in Food Science and Nutrition·João MonteiroBranca M Silva
Oct 27, 2018·Archives of Pharmacal Research·Gil-Im MunYun-Sil Lee
Mar 31, 2005·Phytotherapy Research : PTR·Rajesh AroraRakesh Kumar Sharma
Jan 7, 2005·Journal of Radiation Research·Mustafa Vecdi ErtekinCemal Gündogdu

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