Caffeine and chlordiazepoxide: effects on motor activity in the chronic thalamic rat.

Naunyn-Schmiedeberg's Archives of Pharmacology
A A BorbélyP G Waser

Abstract

The effects of three doses of caffeine and of chlordiazepoxide (CDX) on motor activity were tested in the chronic thalamic rat. In this preparation virtually all cortical, striatal and limbic structures were ablated. A small dose of caffeine had only a weak motor stimulant effect which was succeeded by sedation. Larger doses that are stimulatory in intact animals, depressed motor activity in the thalamic rat. Amphetamine, in contrast to caffeine, produced a substantial motor stimulation. CDX caused a dose-dependent reduction of motor activity, similar to its effect in the intact rat. It is concluded that (a) telencephalic structures are involved in mediating the stimulatory action of caffeine; (b) a sedative component of caffeine may be present, but masked, in the intact animal, and may be due to serotoninergic mechanisms; (c) the presence of limbic structures is not necessary for the sedative effect of CDX.

References

Nov 7, 1974·The New England Journal of Medicine·D J Greenblatt, R I Shader
Dec 5, 1974·The New England Journal of Medicine·D J Greenblatt, R I Shader
Feb 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·A ThithapandhaJ R Gillette
Nov 1, 1971·European Journal of Pharmacology·B A Berkowitz, S Spector
Apr 1, 1967·Experimental and Molecular Pathology·Z GoriM Pollera
Mar 1, 1953·Thorax·L CUDKOWICZ, J B ARMSTRONG
Mar 1, 1953·British Journal of Pharmacology and Chemotherapy·P B DEWS

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Citations

Mar 19, 1991·European Journal of Pharmacology·A A Borbély, P Achermann
Jan 1, 1981·Progress in Neurobiology·J W Phillis, P H Wu

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