PMID: 2122148Jan 1, 1990Paper

Caffeine and human cerebral blood flow: a positron emission tomography study

Life Sciences
O G CameronM Hariharan

Abstract

Positron emission tomography (PET) was used to quantify the effect of caffeine on whole brain and regional cerebral blood flow (CBF) in humans. A mean dose of 250 mg of caffeine produced approximately a 30% decrease in whole brain CBF; regional differences in caffeine effect were not observed. Pre-caffeine CBF strongly influenced the magnitude of the caffeine-induced decrease. Caffeine decreased paCO2 and increased systolic blood pressure significantly; the change in paCO2 did not account for the change in CBF. Smaller increases in diastolic blood pressure, heart rate, plasma epinephrine and norepinephrine, and subjectively reported anxiety were also observed.

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Citations

Jun 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Stavric
Mar 1, 1992·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R S Kahn, H M van Praag
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Oct 27, 2009·NeuroImage·Thomas T Liu, Joy Liau

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