Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1

Molecular and Cellular Neurosciences
Karim A Alkadhi, Ibrahim A Alhaider

Abstract

We have investigated the neuroprotective effect of chronic caffeine treatment on basal levels of memory-related signaling molecules in area CA1 of sleep-deprived rats. Animals in the caffeine groups were treated with caffeine in drinking water (0.3g/l) for four weeks before they were REM sleep-deprived for 24h in the Modified Multiple Platforms paradigm. Western blot analysis of basal protein levels of plasticity- and memory-related signaling molecules in hippocampal area CA1 showed significant down regulation of the basal levels of phosphorylated- and total-CaMKII, phosphorylated- and total-CREB as well as those of BDNF and CaMKIV in sleep deprived rats. All these changes were completely prevented in rats that chronically consumed caffeine. The present findings suggest an important neuroprotective property of caffeine in sleep deprivation.

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Citations

Feb 22, 2018·Neural Plasticity·Enrico SangiovanniFrancesca Calabrese
Jun 20, 2018·The Journal of Pharmacology and Experimental Therapeutics·Karim A Alkadhi
Sep 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaohong XuFuchun Wang
Mar 23, 2017·Molecular Psychiatry·M J Ramaker, S C Dulawa
May 4, 2017·Molecular Neurobiology·Karim A Alkadhi
Oct 8, 2020·Journal of Neuroinflammation·Shaghayegh SadeghmousaviNima Rezaei
Oct 28, 2019·Physiology & Behavior·Aysen CakirNevzat Kahveci

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