PMID: 6402286Apr 1, 1983Paper

Caffeine and unsaturated fat diet significantly promotes DMBA-induced breast cancer in rats

Cancer
J P MintonM G Sriram

Abstract

The following study was carried out to determine the possibility of caffeine being a promoter of breast cancer development in animals consuming vegetable fat. A controlled study, comparing the time of mammary tumor development and the number of tumors was carried out in Sprague-Dawley rats which had been given 20 mg of DMBA at seven weeks of age. This study evaluated the tumor promotional effects of caffeine alone, caffeine and unsaturated fat in combination, unsaturated fat alone, and a standard rat chow diet. The results show that the rats which consumed caffeine and unsaturated fat had the earliest development of tumor and the most multiple tumor occurrence. Average time to tumor development was 95 days. The fat or standard chow rats had an average time to tumor development of 134 and 140 days, respectively. The caffeine-alone rats had a mean time to tumor development of 188 days. The combination of an unsaturated fat diet and caffeine significantly shortened the time to tumor development when compared with the other three groups.

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Citations

Jan 1, 1986·Breast Cancer Research and Treatment·J P MintonT E Webb
Dec 1, 1988·Mutation Research·D A BoothmanA B Pardee
Sep 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yao-Ping LuAllan H Conney
Jan 27, 2004·Journal of Cellular Biochemistry·Allan H Conney
Aug 1, 1985·Medical Hypotheses·J BooyensI E Katzeff
Apr 1, 1988·European Journal of Cancer & Clinical Oncology·H Nagasawa, R Konishi
Oct 15, 1983·International Journal of Cancer. Journal International Du Cancer·C W WelschJ V DeHoog
Mar 15, 1988·International Journal of Cancer. Journal International Du Cancer·T E Rohan, A J McMichael
Oct 15, 1987·International Journal of Cancer. Journal International Du Cancer·C SchairerR N Hoover
Feb 1, 1986·Cancer·H C Polk
Oct 28, 2019·International Journal of Molecular Sciences·Xiangbing MaoJun He
Aug 22, 2021·International Journal of Cancer. Journal International Du Cancer·Kan Hong ZhengLina Mu

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