Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes

Nutrients
Joanna FolwarcznaMartin Gajdoš

Abstract

Diabetes may lead to the development of osteoporosis. Coffee drinking, apart from its health benefits, is taken into consideration as an osteoporosis risk factor. Data from human and animal studies on coffee and caffeine bone effects are inconsistent. The aim of the study was to investigate effects of caffeine at a moderate dose on the skeletal system of rats in two models of experimental diabetes induced by streptozotocin. Effects of caffeine administered orally (20 mg/kg aily for four weeks) were investigated in three-month-old female Wistar rats, which, two weeks before the start of caffeine administration, received streptozotocin (60 mg/kg, intraperitoneally) alone or streptozotocin after nicotinamide (230 mg/kg, intraperitoneally). Bone turnover markers, mass, mineral density, histomorphometric parameters, and mechanical properties were examined. Streptozotocin induced diabetes, with profound changes in the skeletal system due to increased bone resorption and decreased bone formation. Although streptozotocin administered after nicotinamide induced slight increases in glucose levels at the beginning of the experiment only, slight, but significant unfavorable changes in the skeletal system were demonstrated. Administration o...Continue Reading

References

Jan 1, 1990·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·P E SchneiderT Nakamoto
Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T NakamotoM Yazdani
Mar 23, 1995·The New England Journal of Medicine·S R CummingsT M Vogt
Jul 1, 1993·Bone·C H Turner, D B Burr
Sep 1, 1996·The Anatomical Record·C S WinkT Nakamoto
Jun 12, 1999·Annals of Nutrition & Metabolism·M OhtaT Nakamoto
Mar 15, 2001·Bone·W SakamotoS Yukawa
Aug 10, 2002·Annals of Nutrition & Metabolism·Mitsuhiro OhtaKevin A Thomas
Oct 29, 2005·The International Journal of Biochemistry & Cell Biology·Pellegrino Masiello
Dec 16, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ewa K StürmerKlaus M Stürmer
Mar 2, 2006·Critical Reviews in Food Science and Nutrition·Jane V Higdon, Balz Frei
Jun 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H HallströmK Michaëlsson
May 22, 2007·Cellular and Molecular Life Sciences : CMLS·J W Daly
Dec 5, 2008·Journal of Periodontology·Joyce Pinho BezerraMarta Ferreira Bastos
Apr 3, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matthew J SilvaXiaodu Wang
Jun 2, 2009·Archives of Oral Biology·Poliana Mendes DuarteMarta Ferreira Bastos
Sep 23, 2010·Handbook of Experimental Pharmacology·Christa E Müller, Kenneth A Jacobson
Sep 23, 2010·Handbook of Experimental Pharmacology·Marie-Soleil Beaudoin, Terry E Graham
Feb 2, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shing Hwa LiuChingmin Tsai
Mar 2, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J-J BodyJ-Y Reginster
May 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Borzo GharibiBronwen A J Evans
Nov 1, 2011·Folia Histochemica Et Cytobiologica·Grażyna OlchowikMonika Tomaszewska
Mar 10, 2012·The Journal of Biological Chemistry·Shannon H CarrollKatya Ravid
Aug 10, 2012·Journal of Periodontology·Joyce Pinho BezerraMarta Ferreira Bastos
Aug 14, 2012·Journal of Cellular Physiology·Lindsay M CoeLaura R McCabe
Nov 28, 2012·Archives of Medical Science : AMS·Huifang LiuChengqi He
Jan 11, 2013·International Journal of Food Sciences and Nutrition·Shu-Jem SuKuan-Ming Chen
Feb 5, 2013·Frontiers of Medicine·Wenbo Yan, Xin Li
Jun 12, 2013·Molecular Nutrition & Food Research·Joanna FolwarcznaLeszek Sliwiński
Jul 25, 2013·American Journal of Epidemiology·Helena HallströmKarl Michaëlsson
Sep 28, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Salman K BhattiCarl J Lavie
May 17, 2014·PloS One·Helena HallströmLiisa Byberg
Feb 5, 2015·Current Osteoporosis Reports·Ling OeiEdwin H G Oei
Apr 2, 2015·Brazilian Dental Journal·Rander Moreira MacedoSuzie Aparecida de Lacerda
Apr 16, 2015·Journal of Osteoporosis·Tayyab S Khan, Lisa-Ann Fraser
Jun 5, 2015·Journal of Anatomy·Jiwon ShinJaesook Roh

❮ Previous
Next ❯

Citations

Jun 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Piotr LondzinJoanna Folwarczna
May 27, 2021·International Endodontic Journal·Renan Dal-FabbroJoão Eduardo Gomes-Filho
Aug 8, 2021·Journal of Periodontal Research·Omar OmarFaisal Al-Qarni
Feb 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huanhuan XuJun Sheng

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

Statistica
Bluehill
Lunar Prodigy with Encore
StatSoft
Lucia G
OsteoMeasure XP

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.