Caffeine attenuates seizure and brain mitochondrial disruption induced by Tramadol: the role of adenosinergic pathway.

Drug and Chemical Toxicology
Mahedeh SamadiHamidreza Mohammadi

Abstract

Tramadol (TR) is an analgesic drug used to treat moderate-to-severe pain but it induces seizure even at therapeutic doses. The exact mechanism of TR-inducing seizure is not clear but inhibition of the serotonin, GABA, and nitrous oxide (NOS) pathways are the commonly proposed mechanisms. Adenosinergic system has a crucial function in the modulation of seizure. Also, oxidative damage is an unavoidable effect of the seizure. This study was conducted to evaluate the role of the adenosinergic system on the seizure and oxidative stress biomarkers induced by TR using antagonist of the adenosinergic receptors in the Albino mice. For that purpose, generated clonic seizure, as seizure threshold, was evaluated by TR. Caffeine (CAF; 8 mg/kg, i.p.), a nonselective antagonist of adenosine receptors, was administered 1 hour before the seizure induction. The seizure threshold significantly increased by CAF-treated group when compared to TR group (p < 0.001). Oxidative stress biomarkers such as reactive oxygen species, protein carbonyl content, and lipid peroxidation significantly decreased and glutathione content significantly increased by CAF in brain mitochondria compared to the TR group, whereas oxidative biomarkers significantly increased...Continue Reading

References

Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J J Barone, H R Roberts
Dec 1, 1995·Progress in Neurobiology·H F Bradford
Dec 9, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·H L Haas, O Selbach
Dec 29, 2000·Pharmacotherapy·J S GardnerR Alderfer
Jul 20, 2001·British Journal of Anaesthesia·P E Macintyre
Feb 2, 2002·Epilepsy Research·Houman HomayounAhmad Reza Dehpour
Oct 29, 2004·Clinical Pharmacokinetics·Stefan Grond, Armin Sablotzki
Jan 6, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Detlev Boison
Mar 22, 2005·European Journal of Pharmacology·M Olga Rojas-CorralesJuan A Micó
May 5, 2005·The Annals of Pharmacotherapy·Kathy A MarquardtTimothy E Albertson
Apr 18, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Vesna Jovanović-CupićNada Nesić
Apr 6, 2007·Pharmacology & Therapeutics·Jason N Peart, John P Headrick
May 22, 2007·Cellular and Molecular Life Sciences : CMLS·J W Daly
Aug 8, 2008·Basic & Clinical Pharmacology & Toxicology·Ashish K RehniManoj Kumar
Jan 14, 2009·The Veterinary Journal·Enzo VettoratoPetra Cagnardi
Mar 11, 2009·Free Radical Biology & Medicine·Xin GaoHai Yan Zhang
Jun 6, 2009·Seizure : the Journal of the British Epilepsy Association·Jana TchekalarovaPavel Mares
Oct 15, 2009·Pharmacoepidemiology and Drug Safety·Micaela TjäderbornStaffan Hägg
Nov 28, 2009·Pharmacology, Biochemistry, and Behavior·Joanna ListosSylwia Fidecka
Mar 12, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiongwen LvPengli Zhu
Dec 15, 2010·Biochimica Et Biophysica Acta·Catarina V GomesRodrigo A Cunha
Aug 1, 2012·Oxidative Medicine and Cellular Longevity·Carlos Clayton Torres AguiarSilvania Maria Mendes Vasconcelos
Mar 15, 2013·Neurochemistry International·Mauren Assis SouzaLuiz Fernando Freire Royes
Dec 18, 2013·Life Sciences·Rômulo Pillon BarcelosNilda Vargas Barbosa
Jan 30, 2014·Clinical and Experimental Pharmacology & Physiology·Marwa A Ahmed, Adel Kurkar
Oct 22, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·M BarannB Urban
Jan 27, 2015·Journal of Experimental Psychopathology·Lori M HiltSeth D Pollak
Feb 11, 2015·Journal of the Experimental Analysis of Behavior·Justin C StricklandWilliam W Stoops
Apr 25, 2015·Journal of Neurochemistry·David Agustín León-NavarroMairena Martín

❮ Previous
Next ❯

Citations

Jun 2, 2020·Expert Opinion on Drug Metabolism & Toxicology·Mohsen Doostmohammadi, Hamid-Reza Rahimi
Sep 16, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·José Luiz PortelaRobson Luiz Puntel
Oct 13, 2020·Neurologic Clinics·Haley N Phillips, Laura Tormoehlen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.