Caffeine does not attenuate experimentally induced ischemic pain in healthy subjects

Acta Anaesthesiologica Scandinavica
J DellermalmS Grass

Abstract

Caffeine is likely the most widely used psychoactive substance in the world. It is also an analgesic adjuvant and has individual analgesic properties. The latter effect has been attributed to adenosine receptor antagonism, but the site of action is unknown. The aim of this study was to investigate the analgesic properties of caffeine on experimentally induced ischemic pain and to attempt to elucidate whether the site of action is central or peripheral. Seventeen healthy subjects received intravenous (i.v.) regional and systemic infusions of caffeine at 10 mg/kg or placebo in a double-blind, crossover fashion to investigate the site of action for caffeine-induced analgesia. Subjects underwent a sub-maximum effort tourniquet test. Pain scores [visual analogue scale (VAS), 0-100] were assessed every minute up to a maximum of 45 min. The sum of pain scores (SPS, accumulation of VAS scores) was attenuated neither by systemic 2405 (+/-234) nor by i.v. regional caffeine 2427 (+/-190) as compared with placebo 2442 (+/-205), P=0.99 (mean+/-SEM). Time to maximal VAS score did not differ significantly between treatments, P=0.94. There was no correlation between caffeine concentration in plasma and time to maximal pain score, or between SP...Continue Reading

References

Feb 1, 1991·Pain·N WardD Dunner
Sep 1, 1989·Cardiovascular Research·B JonzonL Kaijser
Sep 1, 1985·Stroke; a Journal of Cerebral Circulation·R J Mathew, W H Wilson
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Aug 22, 2000·Acta Physiologica Scandinavica·J Lynge, Y Hellsten
Oct 3, 2000·Clinical Pharmacology and Therapeutics·S DiamondF G Freitag
Jan 5, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W Y Zhang
Jul 31, 2002·Neuroscience Letters·Elena BastiaRosalia Bertorelli
Feb 11, 2003·Progress in Neurobiology·J A RibeiroA de Mendonça
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Robert W MotlRod K Dishman
Feb 2, 2006·European Journal of Pharmacology·Lisa GodfreySusanna M O Hourani
Mar 17, 2006·Medicine and Science in Sports and Exercise·Robert W MotlMatthew R Ely
Nov 14, 2006·Postgraduate Medical Journal·S V AhmedE Jude
Dec 13, 2006·The Journal of Pain : Official Journal of the American Pain Society·Victor MaridakisKevin K McCully

❮ Previous
Next ❯

Citations

Jun 18, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y CaoK Y Ho
Apr 12, 2016·Physiology & Behavior·Christopher D BlackRobert E Hight

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.