Dec 14, 1977

Caffeine enhancement of radiation killing in different strains of Saccharomyces cerevisiae

Molecular & General Genetics : MGG
M A Hannan, A Nasim


Haploid and diploid wild type strains, and three classes of radiation-sensitive mutants of Saccharomyces cerevisiae were tested for enhancement of UV-inactivation by caffeine in growth medium. In addition, the sensitizing effect of caffeine was studied in a haploid and a diploid wild type strain after gamma-irradiation. The drug sensitized the UV-irradiated cells of all strains except those reported to be only slightly UV-sensitive but highly sensitive to ionizing radiation. After gamma-irradiation, no caffeine-enhancement of killing was observed in stationary phase cells of either the haploid or the diploid strain. However, log-phase cells of both strains were partially sensitized. The results of both sets of experiments suggested that caffeine interferes with a recombinational repair occurring in cells in S or G2 phase.

Mentioned in this Paper

Base Excision Repair
Recombination, Genetic
Cell Cycle
Saccharomyces cerevisiae
X-Rays, Nuclear
Black Light, Ultraviolet

About this Paper

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