Caffeine exposure during pregnancy, small for gestational age birth and neonatal outcome - results from the Norwegian Mother and Child Cohort Study

BMC Pregnancy and Childbirth
Dominika ModzelewskaVerena Sengpiel

Abstract

Maternal caffeine intake has repeatedly been linked to babies being born small for gestational age (SGA). SGA babies are known to be at increased risk for adverse neonatal outcomes. The aim of this study was to explore the associations between prenatal caffeine exposure and neonatal health. The study is based on 67,569 full-term singleton mother-infant pairs from the Norwegian Mother and Child Cohort Study. Caffeine consumption from different sources was self-reported in gestational week 22. Neonatal compound outcomes, namely (1) morbidity/mortality and (2) neonatal intervention, were created based on the Medical Birth Registry of Norway. Adjusted logistic regression was performed. Caffeine exposure was associated to SGA (OR = 1.16, 95%CI: 1.10; 1.23) and being born SGA was significantly associated with neonatal health (OR = 3.09, 95%CI: 2.54; 3.78 for morbidity/mortality; OR = 3.94, 95%CI: 3.50; 4.45 for intervention). However, prenatal caffeine exposure was neither associated with neonatal morbidity/mortality (OR = 1.01, 95%CI: 0.96; 1.07) nor neonatal intervention (OR = 1.02, 95%CI: 1.00; 1.05 for a 100 mg caffeine intake increase). Results did not change after additional adjustment for SGA status. Moderate prenatal caffeine...Continue Reading

References

Dec 15, 1983·American Journal of Obstetrics and Gynecology·P KirkinenM Puukka
May 15, 1983·American Journal of Obstetrics and Gynecology·B A Resch, J G Papp
Jan 5, 2002·American Journal of Epidemiology·Mark A KlebanoffDiana G Wilkins
Sep 3, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Smith
Feb 22, 2003·BMJ : British Medical Journal·Kirsten WisborgTine Brink Henriksen
Mar 5, 2003·American Journal of Epidemiology·Michael B BrackenBrian P Leaderer
Nov 25, 2003·Paediatric and Perinatal Epidemiology·Torstein VikGeir Jacobsen
Oct 7, 2005·American Journal of Epidemiology·Bodil Hammer BechJørn Olsen
Apr 28, 2006·American Journal of Epidemiology·Laura M GrossoMichael B Bracken
Aug 26, 2006·American Journal of Epidemiology·Sonia Hernández-DíazMiguel A Hernán
Oct 13, 2006·European Journal of Epidemiology·Kjersti S RønningenJane A Hoppin
Jan 4, 2008·Maternal & Child Nutrition·Anne Lise BrantsaeterHelle Margrete Meltzer
Oct 21, 2009·Paediatric and Perinatal Epidemiology·Roy M NilsenPer Magnus
Jun 11, 2011·Maternal and Child Health Journal·Claire A HoffmireJ Christopher Glantz
Aug 12, 2014·The Lancet Global Health·Michael S Kramer
Feb 10, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Deepak SharmaPradeep Sharma
Apr 12, 2016·International Journal of Epidemiology·Per MagnusCamilla Stoltenberg

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Citations

Apr 12, 2019·Nutrients·Regina WierzejskaBarbara Wojda
Feb 23, 2020·European Archives of Psychiatry and Clinical Neuroscience·Sandrine LamyUNKNOWN Perinatal network of Upper-Normandy
Jun 11, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Feng Jin, Chong Qiao
Jan 28, 2021·Nutrients·Yoko Kawanishi On Behalf Of The Japan Environment And Children's Study Group
Mar 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hangyuan HeLiaobin Chen
Jul 29, 2021·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Rui ZhangNora D Volkow
Dec 6, 2021·American Journal of Obstetrics and Gynecology·Abdal Aziz T ShittuXiaozhong Wen

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Methods Mentioned

BETA
SGA

Software Mentioned

SPSS
Marsal
FoodCalc
R

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