Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling

Hypertension
Tung-Chen YehChing-Jiunn Tseng

Abstract

Recent clinical studies found that fructose intake leads to insulin resistance and hypertension. Fructose consumption promotes protein fructosylation and formation of superoxide. In a previous study, we revealed that inhibition of superoxide production in the nucleus tractus solitarii (NTS) reduces blood pressure. Caffeine displays significant antioxidant ability in protecting membranes against oxidative damage and can lower the risk of insulin resistance. However, the mechanism through which caffeine improves fructose-induced insulin resistance is unclear. The aim of this study was to investigate whether caffeine consumption can abolish superoxide generation to enhance insulin signaling in the NTS, thereby reducing blood pressure in rats with fructose-induced hypertension. Treatment with caffeine for 4 weeks decreased blood pressure, serum fasting glucose, insulin, homeostatic model assessment-insulin resistance, and triglyceride levels and increased the serum direct high-density lipoprotein level in fructose-fed rats but not in control rats. Caffeine treatment resulted in the recovery of fructose-induced decrease in nitric oxide production in the NTS. Immunoblotting and immunofluorescence analyses further showed that caffeine...Continue Reading

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Citations

Mar 5, 2016·European Journal of Nutrition·Anthony ZulliPeter Kruzliak
Aug 28, 2015·Anais Da Academia Brasileira De Ciências·Ernesto A MacongondePatrícia F Schuck
Nov 10, 2017·American Journal of Physiology. Endocrinology and Metabolism·Chih-Wei LiuShou-Dong Lee
Apr 23, 2020·European Journal of Preventive Cardiology·Yoshihiro Fukumoto
Sep 8, 2019·International Journal of Molecular Sciences·Ying-Ying ChenPei-Wen Cheng
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Huanhuan XuJun Sheng
Mar 25, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Si-Ming MaCun-Zhi Liu
May 8, 2019·Heart and Vessels·Yume Nohara-ShitamaYoshihiro Fukumoto
Dec 19, 2019·Frontiers in Pharmacology·Dan LuoXu Ji
Feb 23, 2021·Frontiers in Neuroscience·Lachlan Van SchaikJoseph A Rathner

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