Caffeine Prevents Memory Impairment Induced by Hyperhomocysteinemia

Journal of Molecular Neuroscience : MN
Karem H AlzoubiO F Khabour

Abstract

L-Methionine chronic administration leads to impairment of memory. This impairment is due to the increase in the body oxidative stress, which damages neurons and prevents their firing. On the other hand, caffeine has antioxidant and neuroprotective effects that could prevent impairment of memory induced by L-methionine chronic administration. In the current study, this hypothesis was evaluated. L-methionine (1.7 g/kg/day) was orally administered to animals for 4 weeks and caffeine (0.3 g/L) treatment was added to the drinking water. The radial arm water maze (RAWM) was used to test spatial learning and memory. Antioxidant biomarkers were assessed in the hippocampus tissues using biochemical assay methods. Chronic L-methionine administration induced (short- and long-) term memory impairment (P < 0.05), while caffeine treatment prevented such effect. Additionally, L-methionine treatment reduced catalase and glutathione peroxidase (GPx") enzymatic activities, and reduced glutathione (GSH) to oxidized glutathione (GSSG) ratio. These effects were normalized by caffeine treatment. Activity of superoxide dismutase (SOD) was unchanged by either L-methionine or caffeine treatments. In conclusion, L-methionine induces impairment of memor...Continue Reading

References

Jan 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·X ShiA C Jain
Aug 5, 1993·Nature·M Lafon-CazalJ Bockaert
Jul 4, 1997·The Journal of Biological Chemistry·G R UpchurchJ Loscalzo
Jul 20, 2001·Journal of Neurochemistry·P I HoT B Shea
Aug 14, 2001·Journal of Cellular Biochemistry·V S MujumdarS C Tyagi
Sep 21, 2005·Molecular Psychiatry·J W MuntjewerffM den Heijer
Jul 25, 2006·Schizophrenia Research·Martin StrassnigRohan Ganguli
Jul 28, 2007·Journal of Agricultural and Food Chemistry·José Angel Gómez-RuizJennifer M Ames
Dec 1, 2007·Clinical Interventions in Aging·Catherine McVeigh, Peter Passmore
Feb 22, 2008·Journal of Pineal Research·Giyasettin BaydasViktor S Nedzvetsky
Aug 12, 2008·BMC Pharmacology·Rajeshkumar U KoladiyaBhupesh K Sharma
Aug 12, 2008·Journal of Chemical Neuroanatomy·Panchanan MaitiGovindasami Ilavazhagan
Jan 16, 2009·Bulletin of Experimental Biology and Medicine·A V MakhroE R Bulygina
Mar 14, 2009·Neurochemical Research·Cristie Grazziotin NoschangCarla Dalmaz
Feb 19, 2010·Journal of Alzheimer's Disease : JAD·Joaquim A Ribeiro, Ana M Sebastião
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·Ana Rita CostenlaAlexandre de Mendonça
Mar 2, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sema T KozGiyasettin Baydas
Oct 26, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Annarita CitoLucia Terzuoli
Nov 16, 2010·Free Radical Biology & Medicine·Byung Cheon Lee, Vadim N Gladyshev
Jun 23, 2011·Pharmacology, Biochemistry, and Behavior·Renata Viana AbreuTasso Moraes-Santos
Nov 29, 2011·Clinical Science·Benoit ViolletFabrizio Andreelli
Jan 25, 2012·Neurochemical Research·Anna Dietrich-MuszalskaJolanta Rabe-Jabłońska
Jul 1, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Gautamjeet S MangatNirmal Singh
Mar 1, 2015·Brain Research Bulletin·Nizar M MhaidatKhalid K Abdul-razzak
Jun 19, 2015·Molecular Neurobiology·Karem H AlzoubiNizar M Mhaidat
Nov 29, 2015·Psychiatry Research·Christian NúñezGildas Brébion
Apr 2, 2016·Neurodegenerative Disease Management·Francesco BonettiGiovanni Zuliani
Mar 17, 2017·Advances in Nutrition·Courtney L MillarChristopher N Blesso
Aug 23, 2017·Annual Review of Nutrition·Giuseppe GrossoEdward L Giovannucci

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Citations

Jun 5, 2019·Neurochemical Research·Grace Dos Santos FeijóRenata Padilha Guedes
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna KochmanKatarzyna Janda
Apr 19, 2019·Life Sciences·Karem H AlzoubiHamza I Abu Zamzam
Oct 7, 2019·Psychiatry Research·Karem H AlzoubiAmjad F Mahasneh

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Methods Mentioned

BETA
Assay

Software Mentioned

RAWM
Graph Pad Prism

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