Caffeine prolongs exercise duration in heart failure

Journal of Cardiac Failure
Catherine F NotariusJohn S Floras

Abstract

Caffeine increases submaximal exercise performance in healthy young subjects; its effects on exercise tolerance in heart failure (HF) have not been characterized. To determine whether caffeine increases exercise tolerance in HF, caffeine (4 mg/kg intravenously, equivalent to 2 cups of coffee) or vehicle were infused into 10 treated HF patients (left ventricular ejection fraction 25 +/- 2 %), and 10 age-matched normal subjects (N) on 2 separate days in a double-blind, randomized, crossover design. We measured heart rate, blood pressure, and ventilation at rest and during graded cycling (15 W/minute) to peak effort. Peak oxygen consumption was unaffected in either group. Mean exercise time was unchanged in N (1,013 +/- 87 versus 988 +/- 107 seconds; P = .86) but was significantly increased by caffeine in HF (from 511 +/- 28 to 560 +/- 37 seconds; P = .004) despite an increase in peak minute ventilation (P < .05). Resting and peak blood pressures were higher after caffeine (P < .05) in HF, not N. Caffeine allows HF patients to exercise longer at peak effort.

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Citations

Jun 1, 2012·Journal of Caffeine Research·Catherine F Notarius, John S Floras
Jul 25, 2009·Journal of the American College of Cardiology·Sarah J Goodlin
Jan 27, 2015·Current Treatment Options in Cardiovascular Medicine·Lisa LeMondSarah J Goodlin
May 27, 2008·Journal of the International Society of Sports Nutrition·Bill I CampbellMike Roberts
Sep 21, 2016·European Journal of Heart Failure·Piotr NiewinskiPiotr Ponikowski
Sep 22, 2011·Expert Review of Cardiovascular Therapy·Jessi Khangura, Sarah J Goodlin
Aug 14, 2021·Trends in Cardiovascular Medicine·David Chieng, Peter M Kistler

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