Caffeine Uptake into the Vitreous after Peroral Coffee Consumption.

Ophthalmic Research
Christoph LeisserMartin Kronschläger

Abstract

Caffeine and its metabolites have antioxidant activity, scavenging reactive oxygen species. The aim of our study was to measure caffeine concentrations in vitreous samples after peroral caffeine intake. This prospective study included patients scheduled for 23-G pars plana vitrectomy with membrane peeling due to epiretinal membranes. The study was performed in two parts: in the first part, patients were recruited into three different groups: group A consisted of habitual coffee drinkers who agreed to drink coffee containing 180 mg caffeine 1 h before surgery (n = 10), group B consisted of habitual coffee drinkers who were not offered coffee before surgery (n = 5), and group C consisted of non-habitual coffee drinkers, forming the control group (n = 5). In the second part (group D) patients (habitual coffee drinkers) agreed to give additional blood serum samples for measurement of caffeine concentration. Harvested samples of vitreous (groups A-D), epiretinal membranes (groups A-C), and blood serum samples (group D) were examined for concentrations of caffeine with gas chromatography-mass spectrometry. Samples of 40 eyes of 40 patients were harvested. The concentrations of caffeine in the vitreous samples were 1,998 ± 967 ng/mL i...Continue Reading

References

May 1, 1991·Applied Nursing Research : ANR·P H OkimiM B Fritsche
Jan 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·X ShiA C Jain
Jan 1, 1990·Annual Review of Medicine·N L Benowitz
Jan 1, 1989·Clinical Pharmacokinetics·U BustoE M Sellers
May 1, 1989·Ophthalmology·E J HigginbothamD Hermann
Jan 1, 1987·General Pharmacology·J W Phillis, R E DeLong
Apr 14, 1973·Lancet·V Marks, J F Kelly
Jan 1, 1984·Current Eye Research·S D VarmaR D Richards
Nov 1, 1983·Toxicology and Applied Pharmacology·M P LachanceW J Waddell
Jan 1, 1983·European Journal of Clinical Pharmacology·J Blanchard, S J Sawers
Jul 1, 1982·Clinical Pharmacology and Therapeutics·M BonatiS Garattini
Apr 1, 1994·Photochemistry and Photobiology·K R HightowerD Borchman
Jun 13, 1996·Biochimica Et Biophysica Acta·T P DevasagayamP C Kesavan
Aug 1, 1997·Journal of Clinical Pharmacology·G B KaplanR I Shader
Aug 24, 1999·Cellular and Molecular Neurobiology·D Shi, J W Daly
Feb 3, 2000·The British Journal of Ophthalmology·J B KerrisonN J Newman
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A C NgaiH R Winn
May 23, 2002·The Annals of Pharmacotherapy·Rahamim AvisarDov Weinberger
Jun 14, 2002·Japanese Journal of Ophthalmology·Takashi OkunoTsunehiko Ikeda
Aug 1, 1964·Archives of Ophthalmology·J D PECZON, W M GRANT
Nov 9, 2005·Journal of Glaucoma·Sujatha ChandrasekaranPaul Mitchell
Feb 12, 2008·Investigative Ophthalmology & Visual Science·Jae Hee KangLouis R Pasquale
Sep 16, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shambhu D VarmaSvitlana Kovtun
Sep 18, 2008·Current Eye Research·Berna OzkanYusuf Cağlar
Feb 13, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shambhu D Varma, Kavita R Hegde
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·João CostaAntónio Vaz-Carneiro
Feb 26, 2010·Journal of Alzheimer's Disease : JAD·Marjo H Eskelinen, Miia Kivipelto
Mar 6, 2010·Molecular and Cellular Biochemistry·Shambhu D Varma, Kavita R Hegde
Oct 28, 2010·Acta Ophthalmologica·Shambhu D VarmaSvitlana Kovtun
Mar 13, 2012·Food & Function·Daniel R CardosoLeif H Skibsted
Aug 7, 2012·Acta Ophthalmologica·Naim TeraiRichard Stodtmeister
May 7, 2013·Experimental Eye Research·Martin KronschlägerPer Söderberg
Mar 29, 2014·Acta Ophthalmologica·Linda M MeyerPer G Soderberg
Aug 19, 2014·Mediators of Inflammation·Ana R SantiagoCatarina A Gomes
Jan 22, 2015·Journal of the National Cancer Institute·Erikka LoftfieldRashmi Sinha
Apr 17, 2015·Headache·Werner J Becker
Jul 16, 2015·The Cochrane Database of Systematic Reviews·Xavier Basurto OnaXavier Bonfill Cosp
Dec 20, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Maria H MadeiraAna Raquel Santiago
Jan 23, 2016·Forensic Toxicology·Fabien BévalotJérôme Guitton

❮ Previous
Next ❯

Citations

Oct 30, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Christoph LeisserOliver Findl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Comprehensive Therapy
D L Horwitz
Zeitschrift für Ernährungswissenschaft. Journal of nutritional sciences. Supplementa
W Müller-Limmroth
Deutsche medizinische Wochenschrift
O Strubelt
The American Journal of Cardiology
Thomas L WhitsettH D Christensen
© 2021 Meta ULC. All rights reserved