CAG-repeat polymorphisms in the polymerase γ gene and male infertility: a meta-analysis

Andrologia
Jie ZhangX Xia

Abstract

CAG-repeat in the polymerase γ (POLG) gene encoding polymerase γ for mitochondria is important to spermatogenesis. Compared with a few researchers who raised alteration of CAG-repeat-affected male reproductive ability, others did not find the association between CAG-repeat polymorphisms and male infertility. Therefore, a comprehensive meta-analysis is necessary to determine the association; 13 case-control studies were screened out using keywords search. From these studies, characteristics were extracted for conducting meta-analysis. Odds ratio (OR) and 95% confidence interval (CI) were used to describe the results; the results indicated that CAG-repeat allele was not a risk factor to male infertility (pooled OR = 1.03, 95% CI: 0.79-1.34, P = 0.828). Four different genetic comparisons also demonstrated a negative result: heterozygote comparison (not 10/10 versus 10/10. Pooled OR = 0.99, 95% CI: 0.77-1.27, P = 0.948), homozygote comparison (not 10/not 10 versus 10/10. Pooled OR = 1.08, 95% CI: 0.56-2.06, P = 0.816), the recessive genetic comparison (not 10/not 10 versus not 10/10 + 10/10. Pooled OR = 1.07, 95% CI: 0.58-1.95, P = 0.829) and the dominant genetic comparison (not 10/not 10 + not 10/10 versus 10/10. Pooled OR = 0.97,...Continue Reading

References

Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·D M De Kretser, H W Baker
Mar 5, 2003·Human Reproduction·P May-PanloupP Reynier
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·C KrauszG Forti
May 26, 2005·Gene·Matthew J LongleyWilliam C Copeland
Feb 6, 2008·Fertility and Sterility·Gyun Jee Song, Vivian Lewis
Apr 17, 2008·Reproductive Biomedicine Online·Francesca Nuti, Csilla Krausz
Sep 19, 2008·International Journal of Andrology·Deepa Selvi RaniKumarasamy Thangaraj
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
Aug 6, 2013·Journal of Assisted Reproduction and Genetics·J Poongothai
Apr 29, 2014·Annales d'endocrinologie·Katrien StouffsWilly Lissens

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Citations

Apr 30, 2016·Macromolecular Rapid Communications·Meng LiShiping Zhu
Feb 9, 2021·Human Reproduction Update·Magalie BoguenetPascale May-Panloup

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