CagA-mediated pathogenesis of Helicobacter pylori

Microbial Pathogenesis
Abolghasem Tohidpour

Abstract

Helicobacter pylori has been described as the main etiologic agent of gastric cancer, causing a considerable rate of mortality and morbidity in human population across the world. Although the infection mainly begins asymptomatically, but simply develops to peptic ulcer, chronic gastritis, lymphoma of the gastric mucosa and eventually adenocarcinoma. The major pathological feature of H. pylori infection is due to the activity of the cytotoxin-associated gene A (CagA), a 125-140 kDa protein encoded by the cag pathogenicity island (cagPAI). CagA is also known as the first bacterial onco-protein, ranking the H. pylori-mediated adenocarcinoma as the second most deadly cancer type worldwide. Upon cytoplasmic translocation CagA undergoes interacting with numerous proteins in phosphorylation dependent and independent manners within the gastric epithelial cells. The profound effect of CagA on multiple intracellular pathways causes major consequences such as perturbation of intracellular actin trafficking, stimulation of inflammatory responses and disruption of cellular tight junctions. Such activities of CagA further participate in development of the hummingbird phenotype and gastric cancer. This review is sought to provide a structural...Continue Reading

References

Sep 17, 1992·Nature·S M PowellK W Kinzler
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CovacciN Figura
Jul 25, 1996·The New England Journal of Medicine·L E HanssonH O Adami
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S CensiniA Covacci
Jun 18, 1997·Journal of the National Cancer Institute·R M PeekM J Blaser
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·S SuerbaumM Achtman
May 21, 1999·Science·A CovacciR Rappuoli
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·E D SegalL S Tompkins
Feb 24, 2000·The Journal of Experimental Medicine·A Covacci, R Rappuoli
Dec 6, 2000·The Journal of Experimental Medicine·K OguraM Omata
Oct 31, 2001·Molecular Cell·Y Samuels-LevX Lu
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A IsraelR M Peek
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
May 30, 2002·American Journal of Epidemiology·Abraham M Y NomuraMartin J Blaser
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hideaki HigashiMasanori Hatakeyama
Nov 7, 2002·Molecular Cell·Hitomi MimuroChihiro Sasakawa
Nov 21, 2002·Journal of the National Cancer Institute·Céu FigueiredoManuel Sobrinho-Simões
Apr 30, 2003·The Journal of Cell Biology·Yuri ChurinMichael Naumann
May 3, 2003·The EMBO Journal·Savvas N SavvidesGabriel Waksman
Jun 5, 2003·Nature Reviews. Cancer·Marcos Malumbres, Mariano Barbacid
Jun 5, 2003·Cellular Microbiology·Jiro TanakaChihiro Sasakawa
Jun 6, 2003·Molecular Microbiology·Catherine C McGowanMartin J Blaser
Jun 26, 2003·Molecular Microbiology·Manfred RohdeRainer Haas
Jul 17, 2003·Genes & Development·Daniel PintoHans Clevers
Aug 5, 2003·The Journal of Infectious Diseases·Rahul A ArasMartin J Blaser
Sep 23, 2003·Infection and Immunity·Yi WenGeorge Sachs
Feb 3, 2004·The Journal of Clinical Investigation·Martin J Blaser, John C Atherton
Feb 14, 2004·The Journal of Biological Chemistry·Hideaki HigashiMasanori Hatakeyama
Sep 21, 2004·Proteomics·Matthias SelbachThomas F Meyer
Oct 19, 2004·Nature Immunology·Jérôme VialaRichard L Ferrero
Feb 8, 2005·Current Opinion in Microbiology·Gabriele RiederRainer Haas
Apr 9, 2005·Trends in Microbiology·Matthias Selbach, Steffen Backert
Apr 16, 2005·The Journal of Biological Chemistry·Hideaki HigashiMasanori Hatakeyama
Nov 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fabio BagnoliManuel R Amieva
Dec 16, 2005·Molecular and Cellular Biology·Ryouhei TsutsumiMasanori Hatakeyama

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Citations

Feb 3, 2018·International Journal of Molecular Sciences·Bryce LaFoyaAllan R Albig
Nov 7, 2017·FEMS Microbiology Letters·Xiaoyan ZhangFeifei She
Dec 12, 2017·Journal of Hematopathology·Max I SchreuderBlanca Scheijen
Jun 22, 2018·Future Microbiology·Xiao-Yan YuanMing-Yi Wang
Mar 31, 2018·Minerva gastroenterologica e dietologica·Gianenrico RizzattiAntonio Gasbarrini
Jun 13, 2019·Journal of Cellular Physiology·Masoud KeikhaMohsen Karbalaei
Jul 6, 2017·Frontiers in Cellular and Infection Microbiology·Abolghasem TohidpourAlla B Salmina
Feb 27, 2017·Cellular and Molecular Life Sciences : CMLS·Trevor W Stone, L Gail Darlington
Nov 5, 2019·Frontiers in Immunology·Madison R RoganJere W McBride
Mar 14, 2020·International Journal of Molecular Sciences·Sandra Salillas, Javier Sancho
May 7, 2020·International Journal of Molecular Sciences·Yash Raj RastogiReena V Saini
Feb 20, 2021·Frontiers in Cellular and Infection Microbiology·Hyokeun SongSeongbeom Cho
Mar 2, 2021·World Journal of Gastroenterology : WJG·Vasiliy Ivanovich ReshetnyakIgor Veniaminovich Maev
Jul 26, 2017·Journal of Diabetes and Its Complications·Saud AlzahraniUNKNOWN Diabetes Prevention Program Research Group
Mar 19, 2021·Frontiers in Microbiology·Xiaohong XuYancheng Wen
Apr 27, 2021·Critical Reviews in Microbiology·Xiaojun MaoFabian Cieplik
Jun 3, 2021·International Journal of Molecular Sciences·Paulius JonaitisJuozas Kupcinskas
Jun 11, 2021·Frontiers in Physiology·Diliana Pérez-ReytorKatherine García

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