CAGE displays oncogenic potential and induces cytolytic T lymphocyte activity

Biotechnology Letters
Eunsook ShimDooil Jeoung

Abstract

The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine.

References

Apr 2, 2002·Biochemical and Biophysical Research Communications·Bomsoo ChoDoo-Il Jeoung
Jan 18, 2003·Biochimica Et Biophysica Acta·Saeyoung ParkDoo-Il Jeoung

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