Cajal-like cells in the human upper urinary tract

The Journal of Urology
Roman MetzgerHans-Georg Dietz

Abstract

Interstitial cells of Cajal (ICCs) have an important role in the regulation of gut motility as they are responsible for the slow wave activity of smooth muscle. It is still unknown if ICCs also occur in the human upper urinary tract. Since these cells express and are marked by the c-kit receptor CD117, we investigated its occurrence and distribution along the human upper urinary tract. Tissues from 56 human ureters, spanning proximal, middle and distal ureter segments, were analyzed by indirect immunohistochemistry using the alkaline phosphatase-anti-alkaline phosphatase method and double labeling immunofluorescence on consecutive tissue sections. Several monoclonal and polyclonal antibodies to c-kit receptor were used in combination with various cell markers for histiocytic, mast cell, endothelial, epithelial, neuronal, smooth muscle and stem cell differentiation. The c-kit receptor was found in 3 cell types of the ureter and in round or spindle-shaped cells. Due to their antigenic profile the first one was revealed as mast cells occurring in all layers of the ureteral wall except the urothelium. In contrast, the population of spindle-shaped cells was only marked by c-kit receptor, thus, resembling ICCs. These ICC-like cells w...Continue Reading

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Citations

Jan 18, 2005·Pediatric Surgery International·Roman MetzgerHans-Georg Dietz
Nov 21, 2007·Pediatric Surgery International·Roman MetzgerHolger Till
May 7, 2011·International Urology and Nephrology·Piotr KoledaArtur Pupka
May 2, 2013·International Urology and Nephrology·Wojciech ApoznanskiWitold Pilecki
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Feb 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Roman MetzgerHolger Till
Jun 12, 2012·Journal of Pediatric Urology·Metin GündüzSerafettin Demirci
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