Calbindin D28k-containing neurons are restricted to the medial substantia nigra in humans

Neuroscience
D A McRitchie, G M Halliday

Abstract

A controversy exists in the literature as to whether neurons containing the calcium binding protein calbindin-D28k are located within the human substantia nigra. The point of variance between reports, however, is not the anatomical distribution of these neurons, but rather the delineation of the dorsal border of the substantia nigra. It has been suggested that the dense substance P striatonigral innervation delimits the substantia nigra in the human. The aim of the present study is to re-examine the distribution of calbindin-D28k-positive neurons throughout the substantia nigra using substance P to delimit its borders. Although a few calbindin-D28k-positive neurons were found in the medial cell group of the substantia nigra, the vast majority of positive neurons were located in the adjacent A8 and A10 dopaminergic cell groups. This anatomical location of calbindin-D28k-positive neurons is consistent with previous reports, though our results indicate that when the striatonigral projection is used to define the substantia nigra, calbindin-D28k is not a notable feature of these neurons. This questions the neuroprotective role of this protein in Parkinson's disease.

References

Jan 1, 1992·Acta Neuropathologica·T UchiharaH Tsukagoshi
Aug 1, 1992·Trends in Neurosciences·K G BaimbridgeJ H Rogers
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jul 1, 1991·Journal of Neuropathology and Experimental Neurology·P R HofJ H Morrison
Jan 1, 1990·Acta Neuropathologica·T UchiharaK Kosaka
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M Iacopino, S Christakos
Sep 8, 1990·The Journal of Comparative Neurology·K N WestlundW D Willis
Mar 1, 1986·Neuroscience·J K MaiA C Cuello
Jan 1, 1986·Experimental Brain Research·M Herrera-MarschitzU Ungerstedt
Nov 1, 1989·Trends in Neurosciences·A PersechiniR H Kretsinger
Oct 1, 1989·Annals of Neurology·D C GermanC B Saper
Oct 22, 1986·The Journal of Comparative Neurology·G M Halliday, I Törk
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C R GerfenJ J Miller
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Aug 1, 1993·Neuropathology and Applied Neurobiology·S KatoH Tanabe
Aug 1, 1993·Neuropathology and Applied Neurobiology·P InceK G Baimbridge
Nov 1, 1953·Journal of Neurology, Neurosurgery, and Psychiatry·J G GREENFIELD, F D BOSANQUET

❮ Previous
Next ❯

Citations

May 30, 2013·Journal of Neural Transmission·Hideki HayakawaYoshikuni Mizuno
Nov 20, 1998·Brain Research Bulletin·B HontanillaJ M Giménez-Amaya
Mar 17, 1999·Brain Research Bulletin·D A McRitchieG M Halliday
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
Aug 14, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·T J Counihan, J B Penney
Nov 22, 2007·Parkinsonism & Related Disorders·Natasha Luquin, John Mitrofanis
Jan 19, 2012·The Journal of Comparative Neurology·Stefanie ReyesGlenda M Halliday
Jun 15, 2007·Expert Review of Neurotherapeutics·Ennio EspositoGiuseppe Di Giovanni
Feb 10, 1998·The Journal of Comparative Neurology·T J CounihanJ B Penney
Feb 22, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie L FudgeBrian Ho
Jun 22, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joaquín MartíJosé P Hervás
Jan 1, 1996·The Journal of Comparative Neurology·D A McRitchieG M Halliday
Apr 29, 2018·Neuroscience and Biobehavioral Reviews·E A Kelly, J L Fudge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.