Calcification and membrane formation on the surface of intraocular lenses in a rabbit model

Current Eye Research
Kumiko TanakaTetsuo Tochikubo

Abstract

The aim of this study is to evaluate the calcification and membrane formation in different intraocular lenses (IOLs) models by implanting the IOLs in the subcutaneous plane of a Rabbit model. Experimental study. IOLs were implanted subcutaneously in 13 Japanese albino rabbits for 1 month (n = 6), 3 months (n = 4) and 6 months (n = 3). Five kinds of IOLs were used, including three hydrophobic acrylic IOLs, the MA60AC (Alcon), ZA9003 (AMO) and X-60 (Santen), and two hydrophilic acrylic IOLs, the HP60M and MI60 (Bausch & Lomb). Scanning electron microscopy was used to observe the IOL optics. Energy dispersive x-ray spectroscopy and infrared spectroscopy were used to analyse any surface depositions on the optics, and the modulation transfer function was applied to evaluate the optical performance. Membrane formation was noted to have occurred on the surfaces of the two hydrophobic acrylic IOLs (MA60AC and ZA9003) during the investigation period. The membrane components originated from a serum protein that most likely would be serum albumin. Calcification was noted to have occurred on the surfaces of the two hydrophilic IOLs. However, no calcification was observed on the hydrophobic IOLs, nor was there any membrane formation on the ...Continue Reading

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Citations

Apr 5, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G SchmidingerL Werner
Aug 20, 2014·Journal of Cataract and Refractive Surgery·Virginie BertrandMarie-Claire De Pauw-Gillet

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