Calcification of the acetabular labrum of the hip: prevalence in the general population and relation to hip articular cartilage and fibrocartilage degeneration

Arthritis Research & Therapy
Thelonius HawellekAndreas Niemeier

Abstract

Meniscal calcification is considered to play a relevant role in the pathogenesis of osteoarthritis of the knee. Little is known about the biology of acetabular labral disease and its importance in hip pathology. Here, we analyze for the first time the calcification of the acetabular labrum of the hip (ALH) and its relation to hip cartilage degeneration. In this cross-sectional post-mortem study of an unselected sample of the general population, 170 ALH specimens and 170 femoral heads from 85 donors (38 female, 47 male; mean age 62.1 years) were analyzed by high-resolution digital contact radiography (DCR) and histological degeneration grade. The medial menisci (MM) from the same 85 donors served as an intra-individual reference for cartilage calcification (CC). Scanning electron microscopy (SEM), energy dispersive analysis (ED) and Raman spectroscopy were performed for characterization of ALH CC. The prevalence of CC in the ALH was 100% and that in the articular cartilage of the hip (ACH) was 96.5%. Quantitative analysis revealed that the amount of ALH CC was higher than that in the ACH (factor 3.0, p < 0.001) and in the MM (factor 1.3, p < 0.001). There was significant correlation between the amount of CC in the fibrocartilage...Continue Reading

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Citations

Jun 14, 2020·Journal of Orthopaedic Surgery and Research·Mingjin ZhongWei Lu
Jul 24, 2020·Journal of Orthopaedic Surgery and Research·Giovanni TrisolinoEleonora Olivotto
Jan 28, 2021·Current Reviews in Musculoskeletal Medicine·Parth LodhiaBenjamin G Domb
Sep 21, 2021·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Yoshi KawamuraToshifumi Ozaki
Jul 19, 2020·Osteoarthritis and Cartilage·J Stack, G M McCarthy
Sep 29, 2021·Tissue Engineering. Part B, Reviews·Marco FoscaSophie Verrier

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

R
ImageJ

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