Calcifications in the carotid siphon correlate with silent cerebral small vessel disease in community-dwelling older adults: A population-based study in rural Ecuador

Geriatrics & Gerontology International
Oscar H Del BruttoMauricio Zambrano

Abstract

Using a population-based, cross-sectional design, we aimed to assess whether the presence of calcifications in the carotid siphon (as seen on computed tomography) is associated with silent markers of cerebral small vessel disease (on magnetic resonance imaging) in apparently healthy older adults living in Atahualpa, a rural Ecuadorian village. Stroke-free Atahualpa residents aged ≥60 years identified during a door-to-door survey underwent head computed tomography for assessment of carotid siphon calcifications, and brain magnetic resonance imaging for identification of white matter hyperintensities and silent lacunar infarcts. We evaluated the association between calcifications and markers of small vessel disease using logistic regression models adjusted for demographics and cardiovascular risk factors. The mean age of the 236 participants was 71 ± 8 years, and 139 (59%) were women. Computed tomography readings showed high calcium content in the carotid siphon in 64 individuals (27%), and magnetic resonance imaging showed moderate-to-severe white matter hyperintensities in 51 (30%) and lacunar infarcts in 28 (12%). In the univariate analysis, individuals with high calcium content were older and were more likely to have high fas...Continue Reading

References

Aug 9, 2003·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN Iberoamerican Society of Cerebrovascular Diseases
Sep 27, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Xiang-yan ChenKa Sing Wong
Nov 20, 2010·Neuroradiology·Nu Rhee HongSang-Il Suh
Aug 27, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Daniel BosMeike W Vernooij
Apr 28, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel BosM Arfan Ikram
Mar 20, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Oscar H Del BruttoUNKNOWN Atahualpa Project Investigators
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Dec 3, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Oscar H Del BruttoJulio Lama

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Citations

Dec 17, 2015·Geriatrics & Gerontology International·Naoki SajiTakashi Sakurai
Aug 25, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Oscar H Del BruttoUNKNOWN Atahualpa Project Investigators
Jan 21, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Oscar H Del BruttoBettsy Y Recalde
Nov 2, 2017·Expert Review of Neurotherapeutics·Oscar H Del BruttoVictor J Del Brutto
Sep 1, 2018·JAMA Neurology·Robert W RegenhardtLouis R Caplan
Jan 10, 2021·International Journal of Molecular Sciences·Jakub LitakCezary Grochowski
Sep 26, 2020·Journal of the American College of Cardiology·Jonas W BartstraAnnemarie M den Harder

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