Calcified plaque: measurement of area at thin-section flat-panel CT and 64-section multidetector CT and comparison with histopathologic findings

Radiology
Ammar SarwarUdo Hoffmann

Abstract

The purpose of this study was to assess the blooming artifacts in ex vivo coronary arteries at multidetector computed tomography (CT) and flat-panel-volume CT by comparing measured areas of calcified plaque with respect to the reference standard of histopathologic findings. Three ex vivo hearts were scanned with multidetector CT and flat-panel-volume CT after institutional review board approval. The area of calcified plaque was measured at histopathologic examination, multidetector CT, and flat-panel-volume CT. The plaque area was overestimated at multidetector CT by 400% (4.61/1.15) on average, and the predicted difference between the measurements was significant (3.46 mm(2), P = .018). The average overestimation of plaque area at flat-panel-volume CT was twofold (214% [2.18/1.02]), and the predicted difference was smaller (1.16 mm(2), P = .08). The extent of the blooming artifact in visualizing calcified coronary plaque is reduced by using flat-panel-volume CT.

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Citations

Jan 28, 2014·PloS One·Alfredo Morales PinzónMarcela Hernández Hoyos
Apr 22, 2011·The International Journal of Cardiovascular Imaging·Wisnumurti KristantoMatthijs Oudkerk
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Apr 10, 2021·International Angiology : a Journal of the International Union of Angiology·Ombretta MartinelliRoberto Gattuso

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