Calcifying odontogenic cysts: co-expression of intermediate filament proteins, and immunohistochemical distribution of keratins, involucrin, and filaggrin

Pathology, Research and Practice
K KakudoM Mori

Abstract

The epithelia lining the cyst of five cases of calcifying odontogenic cyst (COC) were evaluated immunohistochemically with the use of monoclonal antibodies (MoAb's) against keratin (PKK1, KL1, K4.62, K8.12) and vimentin, and polyclonal antisera agonist involucrin and filaggrin. Epithelial lining of COC was classified into 1) thin squamous-cell epithelium, 2) ameloblastoma-like, and 3) thin or 4) thick calcifying odontogenic epithelium. Foci consisting of ghost cells or calcified cells were categorized as calcifying epithelial odontogenic tumor (CEOT). Thin squamous-cell epithelium reacted with PKK1, KL1, K4.62, K8.12, and anti-vimentin MoAb's, thus demonstrating the co-expression of keratin and vimentin. Ameloblastoma-like cells showed positive staining with PKK1, KL1, and sometimes with anti-vimentin. Thick calcifying odontogenic epithelial lining showed stratification of cell layers, and the most strikingly reactive zone was the upper intermediate layer, which showed the presence of keratin, involucrin, and a small amount of filaggrin. Cells of this layer might be the most differentiated type of cells in COC. Undifferentiated odontogenic cells of COC masses were characterized by co-expression of keratin and vimentin, and by t...Continue Reading

References

Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·M MoriS Sasaki
Nov 15, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J KimG L Ellis
Oct 6, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K V Badger, D G Gardner
Jul 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P L LukinmaaL Zardi
Aug 4, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K SatomuraM Nagayama
Feb 13, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Eduardo Rodrigues FregnaniOslei Paes de Almeida

Citations

Nov 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·J P Sapp, D G Gardner
Jul 1, 1975·Oral Surgery, Oral Medicine, and Oral Pathology·P D FreedmanJ K Gee
Oct 1, 1985·The Journal of Cell Biology·B A DaleT T Sun
Feb 1, 1986·Journal of the American Academy of Dermatology·B R SmollerS Banks-Schlegel
Aug 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·S SumitomoM Mori
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y TatemotoM Mori
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·J KanitakisJ Thivolet
Apr 1, 1986·Journal of Oral Pathology·M E ItoizA J Klein-Szanto
Jul 1, 1986·Journal of Oral Pathology·Y TajimaN Utsumi
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·J KanitakisJ Thivolet
Jan 1, 1972·Journal of Oral Pathology·O Fejerskov, J Krogh
Feb 1, 1984·Journal of Oral Pathology·P C de WildeF C Ramaekers
Jan 1, 1981·Acta Odontologica Scandinavica·F PraetoriusR A Vickers
Dec 1, 1963·Oral Surgery, Oral Medicine, and Oral Pathology·L GOLD

Related Concepts

Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Ameloblastoma
VIM gene
FLG gene
Profilaggrin
Keratin
Immune Sera
Filaggrin
Epithelium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

Oral Surgery, Oral Medicine, and Oral Pathology
K YamadaM Mori
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
C MascrèsR Vauclair
© 2020 Meta ULC. All rights reserved