Abstract
Calcifying pseudoneoplasm of the neuroaxis (CAPNON) is a rare, slow-growing tumor of a fibro-osseous origin that may present anywhere in the neuroaxis. Although typically benign, symptoms of CAPNONs typically present secondary to compression and surrounding mass effect. Histologically, the tumor has the characteristics of a foreign body reaction with giant cells, ossification, and the formation of psammoma bodies. On imaging, they can easily be confused with malginant lesions such as chondrosarcoma or chondroblastoma or even more benign pathologies like meningioma. We present a case of a patient with an incidentally found calcifying pseudoneoplasm involving the cervicomedullary junction with further involvement of the vertebral artery and the hypoglossal nerve. We also review the literature on these tumors to date. Calcifying pseudoneoplasm of the neuroaxis is a slow-growing, benign, noninfiltrative lesion whose pathogensis and natural history remains unclear. It can appear anywhere in the neuroaxis and does not have a prevelant location. Because of the indolent course and relative rarity of this tumor, there are no current guidelines on the immediate and long-term management of CAPNONs. This entity, although quite rare, should...Continue Reading
References
Oct 1, 1977·Annals of Neurology·P Averback
Jan 1, 1990·Journal of Neurosurgery·F BertoniB M Onofrio
Aug 1, 1994·Human Pathology·D M Smith, A D Berry
Feb 13, 1999·Neuroradiology·D A ShrierJ M Powers
Apr 18, 2000·Spine·H ChangK W Kim
Jan 30, 2002·British Journal of Neurosurgery·M TatkeV Gupta
May 22, 2003·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Giovanni LiccardoBernardo Fraioli
Jun 1, 1963·Neurology·P TIBERIN, A J BELLER
May 12, 2007·Histopathology·N GhosalA S Hegde
Sep 1, 2007·Acta Neuropathologica·Fausto J RodriguezChristopher A Robinson
Feb 5, 2008·Clinical Neurology and Neurosurgery·Paul ParkFrank La Marca
Apr 17, 2009·AJNR. American Journal of Neuroradiology·A H AikenC Glastonbury
Oct 17, 2009·Neurosurgery·Guilherme Ramina MontibellerMakoto Nakamura
Feb 27, 2010·Arthritis and Rheumatism·Denise TongNicholas Manolios
Jun 24, 2010·Clinical Neuropathology·I MohapatraS K Shankar
Dec 24, 2010·Clinical Neuropathology·M OzdemirY S Caglar
Mar 19, 2011·Neurosurgery·Tiffany R HodgesAllan H Friedman
May 5, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Aaron M FletcherErin K O'Brien
Oct 12, 2012·Acta neurochirurgica·M N StienenS Lücke
Nov 23, 2012·Pathology·Alaa A SalimMichael E Buckland
Dec 13, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mark E JentoftHoward T Chang
Feb 12, 2013·Journal of Neurosurgery. Spine·Viktor BartanuszJames M Henry
Feb 12, 2013·Journal of Neurosurgery·Edward E KerrKiarash Shahlaie
Jul 19, 2013·Clinical Neuropathology·Matthew GrabowskiMichael Vogelbaum
Aug 16, 2013·Journal of Neurological Surgery Reports·Yoichi NonakaTakanori Fukushima
Sep 14, 2013·The Neuroradiology Journal·C F MuccioG Esposito
Citations
Apr 8, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Nayuta HigaKazunori Arita
Jul 11, 2018·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Michael A PaoliniAditya Raghunathan
Aug 18, 2018·Journal of Neurosurgery. Pediatrics·Michael M SafaeeNalin Gupta
Mar 13, 2020·British Journal of Neurosurgery·Jian-Qiang LuBill Hao Wang
Dec 18, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kaiyun YangJian-Qiang Lu
Jan 20, 2020·Histopathology·Mai-Lan HoAditya Raghunathan
May 4, 2017·The Neuroradiology Journal·Atin SahaSasan Karimi
Jan 21, 2021·International Journal of Surgical Pathology·Lei YanSarah Hackman
Jan 29, 2021·World Neurosurgery·Kaiyun YangJian-Qiang Lu
Mar 7, 2021·Acta neurologica Belgica·Yujian LiHao Li
Aug 11, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Wei-Qing LiZhi Zhu