Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats

American Journal of Physiology. Renal Physiology
Grzegorz PiechaMarie-Luise Gross

Abstract

Patients with renal insufficiency develop secondary hyperparathyroidism. Monotherapy with active vitamin D or calcimimetics ameliorates secondary hyperparathyroidism. We compared kidney damage in subtotally nephrectomized (SNX) rats treated with active vitamin D (calcitriol) or the calcimimetic R-568. Male Sprague-Dawley SNX and sham-operated (sham-op) rats were randomized into the following treatment groups: SNX + R-568, SNX + calcitriol, SNX + vehicle, sham-op + R-568, sham-op + calcitriol, and sham-op + vehicle. Albuminuria and blood pressure were monitored and kidneys were examined using morphometry, immunohistochemistry, quantitative RT-PCR, and in situ hybridization. Parathyroid hormone concentrations were lowered to the same extent by the two interventions, although phosphorus and the calcium-phosphorus product were reduced only by R-568 treatment. SNX rats developed marked albuminuria, which was significantly reduced in ad libitum- and pair-fed animals treated with R-568 and animals treated with calcitriol. Mean glomerular volume (6.05 +/- 1.46 vs. 2.70 +/- 0.91 mm(3)), podocyte volume (831 +/- 127 vs. 397 +/- 67 microm(3)), the degree of foot process fusion (mean width of foot processes = 958 +/- 364 vs. 272 +/- 35 nm)...Continue Reading

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Citations

Jul 3, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Georg Schlieper, Jürgen Floege
Mar 13, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kumiko NakagawaClaus Peter Schmitt
Apr 28, 2010·The Journal of Biological Chemistry·Alice CavanaughGerda E Breitwieser
Oct 3, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadezda KoleganovaMarie-Luise Gross
Dec 4, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lilla FangGábor Kökény
Mar 17, 2012·Future Cardiology·Cristina Karohl, Paolo Raggi
Jan 14, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael van Husen, Markus J Kemper
Dec 2, 2008·Expert Opinion on Drug Metabolism & Toxicology·Piergiorgio MessaBrigida Brezzi
Dec 19, 2008·Kidney International·Nadezda KoleganovaMarie-Luise Gross
Dec 19, 2008·Kidney International·Ziyad Al-Aly
Aug 16, 2011·Kidney International·Maria P Rastaldi
Feb 22, 2011·Lancet·Alberto OrtizJesus Egido
Mar 12, 2010·Advances in Chronic Kidney Disease·Vicente E Torres
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Mar 7, 2019·American Journal of Physiology. Renal Physiology·Min WuBi-Cheng Liu
Dec 17, 2010·American Journal of Physiology. Renal Physiology·Luis E BeckerMarie-Luise Gross
Oct 25, 2013·American Journal of Physiology. Renal Physiology·Min WuBi-Cheng Liu
May 20, 2011·American Journal of Physiology. Renal Physiology·Nadezda KoleganovaMarie-Luise Gross-Weissmann
Jul 8, 2020·Journal of the American Society of Nephrology : JASN·Sandra Rayego-MateosMarta Ruiz-Ortega
May 24, 2013·American Journal of Physiology. Renal Physiology·Nadezda GutMarie-Luise Gross-Weissmann
Dec 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Qian ZhangXiaojing Wang
May 29, 2015·American Journal of Physiology. Renal Physiology·Tsuneo TakenakaHiromichi Suzuki

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