Calcineurin activation contributes to noise-induced hearing loss

Journal of Neuroscience Research
Shujiro B MinamiJosef M Miller

Abstract

Acoustic overstimulation increases Ca(2+) concentration in auditory hair cells. Because calcineurin is known to activate cell death pathways and is controlled by Ca(2+) and calmodulin, this study assessed the role of calcineurin in auditory hair cell death in guinea pigs after intense noise exposure. Immediately after noise exposure (4-kHz octave band, 120 dB, for 5 hr), a population of hair cells exhibited calcineurin immunoreactivity at the cuticular plate, with a decreasing number of positive-stained cells on Days 1-3. By Day 7, the levels of calcineurin immunoreactivity had diminished to near control, non-noise exposed values, concomitant with an increasing loss of hair cells. Staining of hair cell nuclei with propidium iodide (PI), restricted to calcineurin-immunopositive cells, indicated breakdown of cell membranes symptomatic of incipient cell death. The local application of the calcineurin inhibitors, FK506 and cyclosporin A, reduced the level of noise-induced auditory brain stem response threshold shift and hair cell death, indicating that calcineurin is a factor in noise-induced hearing loss. The results suggest that calcineurin inhibitors are of potential therapeutic value for long-term protection of the morphologic ...Continue Reading

References

Mar 1, 1976·Acta Oto-laryngologica·J E HawkinsS L Coombs
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Dec 1, 1995·The Journal of Allergy and Clinical Immunology·R L Kincaid
Jan 1, 1995·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H YamaneA Kojima
Dec 16, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J A Tumlin
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·A FridbergerB Flock
Sep 11, 1998·Science·M A SussmanJ D Molkentin
Feb 24, 1999·Nature·G J Nabel
May 13, 1999·Progress in Neurobiology·M MoriokaE Miyamoto
Aug 7, 1999·Audiology & Neuro-otology·K K OhlemillerL L Dugan
Nov 24, 1999·The Journal of Biological Chemistry·A AsaiT Kirino
Feb 17, 2000·Hearing Research·D M Prieskorn, J M Miller
Mar 20, 2001·Nature Reviews. Molecular Cell Biology·M P Mattson
Jul 10, 2001·The Journal of Biological Chemistry·V Sée, J P Loeffler
Aug 18, 2001·The Journal of Biological Chemistry·J L GoochH E Abboud
Jun 22, 2002·The Journal of Biological Chemistry·Da-Ting Lin, James D Lechleiter
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Min-Jung KimYong-Keun Jung
Nov 30, 2002·Trends in Pharmacological Sciences·Stefano Schiaffino, AntonioL Serrano
Mar 6, 2003·Brain Research·Yoshimitsu OhinataJochen Schacht
May 14, 2003·Hearing Research·Fenxia HouLihua He
Jun 19, 2003·The Journal of Biological Chemistry·Andres A Caro, Arthur I Cederbaum
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Nov 19, 2003·Biochemical and Biophysical Research Communications·Hengming Ke, Qing Huai
Nov 19, 2003·Biochemical and Biophysical Research Communications·Kimberly L Dodge, John D Scott
Nov 25, 2003·The Journal of Biological Chemistry·Hai-Yan WuHideki Matsui
Dec 31, 2003·Cell·Michelle AartsMichael Tymianski
Jan 27, 2004·The Journal of Biological Chemistry·Jennifer L GoochHanna E Abboud

❮ Previous
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Citations

Jan 13, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wei HuMei-Ying Lin
May 14, 2011·Journal of the Association for Research in Otolaryngology : JARO·Christopher C LiuJohn S Oghalai
Sep 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fu-Quan ChenSu-Hua Sha
Apr 7, 2011·International Journal of Nanomedicine·Weikai ZhangJing Zou
Jan 21, 2011·Expert Opinion on Emerging Drugs·Naoki Oishi, Jochen Schacht
Dec 5, 2006·Hearing Research·Colleen G Le PrellJosef M Miller
Dec 23, 2006·Hearing Research·Richard D KopkeBen J Balough
Oct 24, 2006·Neurobiology of Disease·Yeasmin TaheraBarbara Canlon
Aug 9, 2005·Hearing Research·Isao UemaetomariAkira Hara
Jan 31, 2013·Hearing Research·Erik C Böttger, Jochen Schacht
Oct 11, 2005·Drug Discovery Today·Eric D Lynch, Jonathan Kil
Apr 16, 2015·BioMed Research International·Teru KamogashiraTatsuya Yamasoba
Sep 23, 2014·PloS One·Andrew C LysaghtKonstantina M Stanković
Dec 6, 2016·Expert Opinion on Investigational Drugs·Su-Hua Sha, Jochen Schacht
May 26, 2017·International Journal of Audiology·Belde Kasap-DemirSalih Kavukçu
Apr 19, 2017·Assay and Drug Development Technologies·Hermann A M Mucke
Dec 21, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Mathieu PetremannJonas Dyhrfjeld-Johnsen
Oct 19, 2007·Journal of Neuroscience Research·Daisuke YamashitaJosef M Miller
Mar 8, 2006·Journal of Neuroscience Research·M Angeles Vicente-Torres, Jochen Schacht
Apr 28, 2020·Human Molecular Genetics·Karina LezirovitzJeanne Oiticica
Nov 14, 2015·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Yong-Qiang YuMing Zhang
Apr 27, 2019·Antioxidants·Chisato Fujimoto, Tatsuya Yamasoba
Dec 5, 2019·The Journal of the Acoustical Society of America·Rick P C Cousins
Mar 17, 2021·Cell Biology and Toxicology·Zhiwei ZhengYingzi He
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Zu-Hong HeSu-Hua Sha

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