PMID: 11922891Apr 2, 2002Paper

Calcineurin and hypertrophic heart disease: novel insights and remaining questions

Cardiovascular Research
Orlando F BuenoLeon J De Windt

Abstract

In the past 2 years, an emerging body of research has focused on a novel transcriptional pathway involved in the cardiac hypertrophic response. Ever since its introduction, the significance of the calcineurin-NFAT module has been subject of controversy. The aim of this review is to provide both an update on the current status of knowledge and discuss the remaining issues regarding the involvement of calcineurin in hypertrophic heart disease. To this end, the molecular biology of calcineurin and its direct downstream transcriptional effector NFAT are discussed in the context of the genetic studies that established the existence of this signaling paradigm in the heart. The pharmacological mode-of-action and specificity of the calcineurin inhibitors cyclosporine A (CsA) and FK506 is discussed, as well as their inherent limitations to study the biology of calcineurin. A critical interpretation is given on studies aimed at analyzing the role of calcineurin in cardiac hypertrophy using systemic immunosuppression. To eliminate the controversy surrounding CsA/FK506 usage, recent studies employed genetic inhibitory strategies for calcineurin, which confirm the pivotal role for this signal transduction pathway in the ventricular hypertro...Continue Reading

References

Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P N CockerillM A Vadas
Dec 22, 1995·The Journal of Biological Chemistry·M MuthuchamyD F Wieczorek
Mar 1, 1996·Circulation Research·J PalermoJ Robbins
May 3, 1996·Science·A A Geisterfer-LowranceJ G Seidman
Feb 1, 1996·The Journal of Experimental Medicine·B W ZhangJ G Seidman
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·X Lin, D L Barber
Dec 13, 1996·Science·M R HodgeL H Glimcher
Apr 1, 1997·Journal of Neurochemistry·U S KayyaliH Potter
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
Dec 31, 1997·The Journal of Clinical Investigation·J C BowmanP M Buttrick
Feb 14, 1998·The Journal of Clinical Investigation·M A SussmanT R Kimball
Jul 11, 1998·The Journal of Biological Chemistry·M M LaiS H Snyder
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J W AdamsG W Dorn
Sep 11, 1998·Science·M A SussmanJ D Molkentin
Sep 17, 1998·Journal of Molecular and Cellular Cardiology·M MuthuchamyD F Wieczorek
Oct 14, 1998·The Journal of Clinical Investigation·Q YangJ Robbins
Oct 15, 1998·Nature Medicine·Z LuoK Walsh
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·U MendeE J Neer
Feb 18, 1999·Molecular and Cellular Biology·C W ChowR J Davis

❮ Previous
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Citations

Aug 10, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Camilla CalvieriMassimo Volpe
Feb 16, 2008·Basic Research in Cardiology·Hamid el Azzouzi, Leon J De Windt
Nov 19, 2003·Biochemical and Biophysical Research Communications·Hengming Ke, Qing Huai
Oct 2, 2003·Journal of Molecular and Cellular Cardiology·Katherine E Yutzey, D Woodrow Benson
Nov 30, 2002·Trends in Pharmacological Sciences·Stefano Schiaffino, AntonioL Serrano
Feb 15, 2003·Trends in Cardiovascular Medicine·David C Hill-EubanksMark T Nelson
Aug 6, 2003·Trends in Molecular Medicine·Oliver Ritter, Ludwig Neyses
Jun 7, 2011·Acta Pharmacologica Sinica·Nasrin Nejatbakhsh, Zhong-ping Feng
Jul 20, 2010·Nature Medicine·Joerg HeinekeJeffery D Molkentin
Apr 24, 2008·Cardiovascular Research·Renée Ventura-ClapierVladimir Veksler
Aug 30, 2013·Cardiovascular Research·Eunhee ChungLeslie A Leinwand
Dec 9, 2010·European Heart Journal·Giovana S Di MarcoMarcus Brand
Oct 23, 2010·Journal of Cardiovascular Pharmacology·Atta U ShahbazKarl T Weber
Feb 27, 2009·American Journal of Physiology. Cell Physiology·Anand Mohan Prasad, Giuseppe Inesi
Jan 1, 2007·Future Cardiology·Matthias Hallhuber, Oliver Ritter
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Joerg HeinekeKai C Wollert
Jul 28, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Sheng-Huang ChangWei-Wen Kuo
Jul 4, 2015·Proteomics. Clinical Applications·Adam R Wende
Sep 1, 2007·The Journal of Physiology·Aleksey V ZimaLothar A Blatter
Mar 22, 2007·Journal of Ethnopharmacology·Qing-Song JiangQin Wu
Oct 9, 2003·The Journal of Urology·Kunihiro NozakiHideki Matsui
Nov 9, 2011·Journal of Molecular and Cellular Cardiology·Joerg Heineke, Oliver Ritter
Oct 27, 2009·Journal of Molecular and Cellular Cardiology·Joerg HeinekeJeffery D Molkentin
Sep 28, 2005·Expert Opinion on Therapeutic Targets·Beate Fiedler, Kai C Wollert
Mar 20, 2004·Expert Review of Cardiovascular Therapy·María A FortuñoJavier Díez
Jan 16, 2004·Transplantation·David A J NealGraeme J M Alexander
Jan 28, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christine M Liberatore, Katherine E Yutzey
May 17, 2003·Circulation Research·Paul B BushdidKatherine E Yutzey
Feb 23, 2005·Circulation·Natalie BurkardOliver Ritter
Sep 9, 2017·PloS One·Ashraf Yusuf RangrezDerk Frank
Aug 29, 2006·Nature Reviews. Molecular Cell Biology·Joerg Heineke, Jeffery D Molkentin

❮ Previous
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