Calcineurin-dependent and calcineurin-independent signal transduction pathways activated as part of pancreatic growth

Pancreas
Mitsuo TashiroJohn A Williams

Abstract

We have recently reported that pancreatic growth driven by cholecystokinin released endogenously by feeding the synthetic trypsin inhibitor camostat requires the Ca-activated phosphatase calcineurin. In the present study, we evaluated a number of signal transduction pathways for their activation as part of the growth response and whether their activation was dependent on calcineurin. Male ICR mice were fed with either chow or chow plus 1 mg/g of camostat. FK506 was administered at 3 mg/kg. After various times from 12 hours to 10 days, pancreatic samples were prepared and assayed for activity of various signal transduction pathway components. Camostat feeding increased the activation of extracellular signal-regulated kinases, c-Jun NH2-terminal kinases, and phosphorylation of the translation factor eukaryotic initiation factor 4E and activated the mammalian target of rapamycin pathway that leads to phosphorylation of the ribosomal protein S6 and of the eukaryotic initiation factor 4E binding protein but with different time courses. Treatment of mice with the calcineurin inhibitor FK506 totally blocked c-Jun NH2-terminal kinase activation, partially blocked the mammalian target of rapamycin pathway, and had no effect on extracell...Continue Reading

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Citations

Aug 8, 2006·Current Opinion in Gastroenterology·John A Williams
Mar 31, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lili GuoJohn A Williams
Aug 20, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria Dolors SansJohn A Williams
Aug 28, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen J CrozierJohn A Williams
Mar 13, 2012·The Journal of Clinical Investigation·Jaroslaw DanilukCraig D Logsdon
Apr 15, 2006·The Journal of Physiology·Stephen J CrozierJohn A Williams
Dec 2, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Megan D BaumlerGuy E Groblewski
Nov 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lili GuoJohn A Williams
Mar 22, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen J CrozierJohn A Williams
Aug 12, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bryan J HoltzJohn A Williams

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