Calcineurin homologous protein isoform 2 supports tumor survival via the sodium hydrogen exchanger isoform 1 in non-small cell lung cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Wayne Taylor CottleJoseph John Provost

Abstract

Maintaining intracellular pH is crucial for preserving healthy cellular behavior and, when dysregulated, results in increased proliferation, migration, and invasion. The Na+/H+ exchanger isoform 1 is a highly regulated transmembrane antiporter that maintains pH homeostasis by exporting protons in response to intra- and extracellular signals. Activation of Na+/H+ exchanger isoform 1 is exquisitely regulated by the extracellular environment and protein cofactors, including calcineurin B homologous proteins 1 and 2. While Na+/H+ exchanger isoform 1 and calcineurin B homologous protein 1 are ubiquitously expressed, calcineurin B homologous protein 2 shows tissue-specific expression and upregulation in a variety of cancer cells. In addition, calcineurin B homologous protein 2 expression is modulated by tumorigenic extracellular conditions like low nutrients. To understand the role of calcineurin B homologous protein 2 in tumorigenesis and survival in lung cancer, we surveyed existing databases and formed a comprehensive report of Na+/H+ exchanger isoform 1, calcineurin B homologous protein 1, and calcineurin B homologous protein 2 expression in diseased and non-diseased tissues. We show that calcineurin B homologous protein 2 is upr...Continue Reading

References

Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·X Lin, D L Barber
Dec 14, 1999·The Journal of Biological Chemistry·X LinD L Barber
Dec 18, 2002·The Journal of Cell Biology·Sheryl P Denker, Diane L Barber
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Youssef Ben AmmarShigeo Wakabayashi
May 20, 2006·The EMBO Journal·Youssef Ben AmmarShigeo Wakabayashi
Jun 15, 2007·Current Opinion in Nephrology and Hypertension·Marcel E MeimaDiane L Barber
Feb 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kuniyuki NakamuraMitsuo Iida
Mar 11, 2008·European Journal of Cell Biology·Christian StockStephan J Reshkin
Mar 18, 2009·Bioinformatics·Cole TrapnellSteven L Salzberg
May 14, 2009·Pflügers Archiv : European journal of physiology·Christian Stock, Albrecht Schwab
Dec 15, 2010·American Journal of Physiology. Cell Physiology·Christine MartinChristian Stock
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 12, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Qing-Hua LiTian-Xiang Pang
Dec 23, 2011·American Journal of Physiology. Renal Physiology·Francesca Di SoleVictor Babich
Mar 1, 2012·Current Pharmaceutical Design·Ser Yue LooMarie Veronique Clement
Dec 21, 2012·Chemical Biology & Drug Design·Joseph J Provost, Mark A Wallert
Feb 9, 2013·Cancer Research·Schammim R Amith, Larry Fliegel
Feb 20, 2013·Journal of Cell Science·Frances R BalkwillThorsten Hagemann
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephan Joel ReshkinRosa Angela Cardone
May 30, 2014·Nature·Min-Sik KimAkhilesh Pandey
Jan 22, 2015·Meta Gene·Amira Ahmed HammamSarah Mahmoud
Jan 24, 2015·Science·Mathias UhlénFredrik Pontén
Jul 15, 2015·Recent Patents on Anti-cancer Drug Discovery·Mohit SharmaRaghu Radhakrishnan
Dec 23, 2016·British Journal of Cancer·Dimitrios Anastasiou
Feb 17, 2017·Journal of Cell Science·Katharine A WhiteDiane L Barber
Nov 23, 2017·Nucleic Acids Research·Irene PapatheodorouRobert Petryszak
Mar 27, 2018·Acta Physiologica·M FlinckS F Pedersen
Jul 4, 2018·Molecular Cancer Research : MCR·Xiaohui ZhaoNingfang Ma
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 9, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuo LiangCarola Hunte

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-Seq
Protein Assay
Fluorescence
Knock down
xenograft
Assay

Software Mentioned

Origene
iRAP
VisionWorks
FASTQ
TopHat
Vision Works LS

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

Advances in Enzymology and Related Areas of Molecular Biology
C B KleeM J Hubbard
Current Biology : CB
Patrick G Hogan, Huiming Li
Current Topics in Cellular Regulation
J AramburuC B Klee
© 2021 Meta ULC. All rights reserved