PMID: 25785904Mar 19, 2015Paper

Calcinosis cutis presenting in the context of long-term therapy for chronic myeloid leukemia: a case report and review of the literature

Wounds : a Compendium of Clinical Research and Practice
Igor AltmanWilliam J Ennis

Abstract

Calcinosis cutis is a poorly understood process in which calcium salts deposit in the skin and subcutaneous tissues. Due to its multifactorial pathogenesis, several subtypes and potential etiologies have been described. Presented here is a case of bilateral pretibial calcinosis cutis in a patient on long-term tyrosine kinase inhibitor therapy for chronic myeloid leukemia. The patient initially presented with a right tibial ulceration treated with multiple surgical debridements, antibiotics, and negative pressure wound therapy. The wound was ultimately closed with a split-thickness skin graft. Relevant literature is examined and several possible mechanisms are discussed.

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