Calcinosis preferentially affects the thumb compared to other fingers in patients with systemic sclerosis

Scandinavian Journal of Rheumatology
R GauharA L Herrick

Abstract

Although Raynaud's phenomenon often spares the thumb, clinical experience suggests conversely that, in patients with systemic sclerosis (SSc), the thumb is frequently affected by calcinosis (as is demonstrated on plain radiographs). Our aim was to investigate the hypothesis that, in patients with SSc, thumbs are more commonly affected by calcinosis than other digits. Sixty-eight hand radiographs with at least one area of calcinosis were identified. Each digit on both hands of each patient was assigned a severity score on a scale from 0 to 3 (0 = no calcinosis, 3 = most severe). The scoring was completed twice, including and excluding the metacarpals. Right hands were found to be associated with slightly higher scores than left hands [estimate 0.14, 95% confidence interval (CI) 0.03-0.26]. Scores were lower for other fingers compared to thumbs. There was strong evidence (p < 0.0001) of a trend of decreasing severity moving from the thumb to the little finger. There was no evidence that the pattern of severity across the fingers was different on left and right hands (p = 0.77). The results were similar whether or not metacarpals were included. The thumb is affected by calcinosis more than other digits, followed by the index finge...Continue Reading

References

Jan 18, 2006·Annals of the Rheumatic Diseases·J AvouacY Allanore
Feb 18, 2009·Annals of the Rheumatic Diseases·L MouthonS Poiraudeau
Mar 3, 2010·The Journal of Rheumatology·Batsi ChikuraAriane L Herrick
Sep 25, 2010·Seminars in Arthritis and Rheumatism·Sophie KoutaissoffFrédéric A Houssiau
Dec 7, 2010·Annals of the Rheumatic Diseases·J AvouacY Allanore
Aug 27, 2014·Arthritis Care & Research·Lorinda ChungUNKNOWN Scleroderma Clinical Trials Consortium Calcinosis Working Group

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Citations

Jul 20, 2017·Modern Rheumatology·Sneha Pai, Vivien Hsu
Aug 21, 2018·Current Opinion in Rheumatology·Antonia ValenzuelaLorinda Chung
Aug 29, 2020·Current Rheumatology Reports·Carrie RichardsonJohn Varga
Mar 25, 2019·Journal of Scleroderma and Related Disorders·Murray BaronAlessandra Vacca
Mar 24, 2021·Clinical Rheumatology·Diane MarRobert M Fairchild

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