PMID: 9558309May 19, 1998Paper

Calciphylaxis: pathogenesis and therapy

Journal of Cutaneous Medicine and Surgery
R L Worth

Abstract

Calciphylaxis is a rare, painful and debilitating disease in which calcification of the skin and subcutaneous tissues or of internal organs can lead to skin necrosis, discolouration, and other skin lesions. The typical patient has end-stage renal disease (ESRD) and hyperparathyroidism. Selye originally characterized this syndrome in rats and distinguished it from other syndromes of abnormal calcification by the following sequence: sensitizers, latent period, and challengers. There has been recent debate regarding misdiagnosis and failure to differentiate this category of patients even in clinical studies. In this article the clinical manifestations of calciphylaxis are described; the importance of distinguishing this condition from other calcification syndromes is explained; risk factors, sensitizers, and challenges are reviewed; treatments of choice are discussed; and the merits of parathyroidectomy are evaluated. It is important to consider calciphylaxis in a differential diagnosis of calcification syndromes and in treating patients with ESRD and hyperparathyroidism, because early diagnosis and treatment can interrupt the progression of the disease process; the disease is painful and debilitating; and inappropriate treatment ...Continue Reading

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Citations

Feb 8, 2007·The American Journal of Dermatopathology·J Andrew Carlson, Ko-Ron Chen
Mar 18, 2010·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Behnam TehraniChayan Chakraborti
Feb 1, 2003·Clinical and Experimental Dermatology·S P R LimB B Tan
Feb 4, 2005·International Journal of Dermatology·Ricardo Luis GalimbertiGastón Galimberti
Aug 24, 2007·Southern Medical Journal·Sagar U Nigwekar
Apr 6, 2004·The International Journal of Artificial Organs·A NakosM Misra
Feb 9, 2000·American Journal of Clinical Pathology·L R Essary, M R Wick
Oct 30, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T PodymowK D Burns
Jul 27, 2011·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Clarissa Morais Busatto GerhardtJane Marcy Neffá Pinto
Mar 7, 2001·Journal of Cutaneous Medicine and Surgery·J AlainJ Baril
Apr 14, 2000·The Laryngoscope·M D KriskovichJ R Haller
Sep 26, 2001·Archives of Pathology & Laboratory Medicine·I MirzaH El-Fanek
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D T JaniganA S MacDonald

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