Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis

Journal of Dermatological Science
Paola LovatoMads Røpke

Abstract

Psoriasis vulgaris is characterised by epidermal hyper-proliferation and infiltration of immune cells including dendritic cells (DCs) and T cells. The inflammation is driven by a complex interplay between immune and skin cells involving interleukin (IL)-17A, IL-23 and TNF-α as key drivers. The calcipotriol/betamethasone dipropionate two-compound fixed combination product is widely used for topical treatment of psoriasis. However, the mechanism behind its high efficacy has not been elucidated in detail. Here, we investigated and compared the immune modulatory effects of betamethasone, calcipotriol and the combination in ex vivo cultures of psoriatic skin and in vitro cultures of primary human cells that recapitulate key cellular activities of psoriatic inflammation. The immune modulatory effect of the treatments on psoriatic skin and on in vitro differentiated Th1/Th17 cells, Tc1/Tc17 cells, monocyte-derived inflammatory dendritic cells and primary keratinocytes was assessed by a panel of inflammatory and phenotypic related transcription factors and cytokines. The expression was evaluated by both gene and protein analysis. Compared to vehicle control or mono-treatments, the effect of calcipotriol/betamethasone combination was si...Continue Reading

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Citations

Sep 25, 2016·Drugs·Esther S Kim, James E Frampton
Sep 25, 2017·Dermatologic Therapy·Andrea ChiricozziFrancesca Prignano
Apr 4, 2020·Expert Opinion on Drug Safety·Victoria Amat-Samaranch, Lluís Puig
Sep 13, 2019·Postgraduate Medical Journal·Qian WuHai-Feng Pan
May 13, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Gabriella FabbrociniAnthony Bewley
Apr 12, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Li-Wei RanSi-Si Yu
Sep 10, 2019·Expert Review of Respiratory Medicine·Rakhee K RamakrishnanQutayba Hamid
Nov 6, 2020·Inflammopharmacology·Madhur D ShastriPhilip M Hansbro

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