Calcitonin and bone mass status in congenital hypothyroidism

Calcified Tissue International
N Demeester-MirkineJ Corvilain

Abstract

Calcitonin (CT) deficiency and its possible repercussions on bone mass were studied in a group of 9 adult patients (7 females, 2 males) with congenital hypothyroidism of dysgenetic origin. Using a new extraction method (exCT) which considerably improves the sensitivity and the specificity of the assay for CT-monomer, we measured CT levels before and after a short calcium (Ca) stimulation test (2 mg Ca/kg over 5 minutes) to evaluate C-cell secretory reserve. Mean basal plasma CT concentrations were lower in the hypothyroid women (mean +/- SEM: 0.6 +/- 0.1 pg/ml) than in 30 normal female controls (1.7 +/- 0.2 pg/ml, P less than 0.001). Serum calcium increased similarly in the two groups, but postinfusion CT levels were lower in the hypothyroid women, (1.7 +/- 0.2 pg/ml) than in normal women (16.8 +/- 2.9 pg/ml), P less than 0.001. Hypothyroid women showed a 10% reduction in bone mineral content at the diaphyseal site in the radius, 0.840 +/- 0.037 g/cm, compared with normal age-matched controls, 0.930 +/- 0.020 g/cm, (P less than 0.05). Our study demonstrates the existence of a profound CT-monomer deficiency in adult patients with thyroid agenesis or dysgenesis. Both calcitonin deficiency and thyroid hormone treatment could play ...Continue Reading

References

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Citations

Jun 1, 1996·European Journal of Pediatrics·G SaggeseC Ceccarelli
Sep 1, 1991·Calcified Tissue International·G Tarján, P Lakatos
Jul 5, 2002·Thyroid : Official Journal of the American Thyroid Association·Peter Vestergaard, Leif Mosekilde
May 12, 2000·Thyroid : Official Journal of the American Thyroid Association·P VestergaardL Mosekilde
Dec 19, 2002·The Journal of Clinical Investigation·Ana O HoffRobert F Gagel
Jul 27, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·L TümerA Bideci
Jul 24, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Pisit PitukcheewanontGertrude Costin
Sep 10, 2004·Clinical Endocrinology·Elaine Murphy, Graham R Williams
Aug 3, 2004·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·R H C BonserP J Butler
Jul 1, 2008·Bone·J H Duncan Bassett, Graham R Williams
Dec 23, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M DaripaM C Foss
Dec 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Adriane de A C DemartiniLuiz de Lacerda Filho
Apr 1, 1995·Journal of Endocrinological Investigation·G WeberG Chiumello

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