PMID: 6134414Jan 1, 1983Paper

Calcitonin and insulin secretion in normal man: study with somatostatin and calcium

Acta diabetologica latina
F Caviezel, R Mangili

Abstract

An increase in extracellular calcium concentration abolishes somatostatin-induced inhibition of insulin release from rat pancreas in vitro; since calcium fails to have a similar effect in vivo, and calcitonin (CT) is capable of inhibiting insulin release, we investigated calcium-stimulated CT secretion during somatostatin administration in normal human males. No significant differences between calcium-stimulated CT secretion during somatostatin infusion and in basal conditions were found. In addition, we confirmed that endogenous CT elicited by calcium administration significantly reduces basal insulin secretion. Thus, we suggest that calcium-induced CT release in vivo may counteract the reversal effect of calcium on the suppressor activity of somatostatin on insulin secretion as shown in vitro.

References

Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·S A MetzR P Robertson
Oct 6, 1975·Biochemical and Biophysical Research Communications·T TaminatoH Imura
Aug 1, 1978·Metabolism: Clinical and Experimental·L CantalamessaM Peracchi
Oct 8, 1974·Biochemical and Biophysical Research Communications·D L Curry, L L Bennett
Dec 1, 1980·The Journal of Clinical Endocrinology and Metabolism·R TorellaF D'Onofrio

❮ Previous
Next ❯

Citations

Jan 1, 1986·Acta diabetologica latina·S SgambatoP Tesauro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.