PMID: 11932208Apr 5, 2002Paper

Calcitonin: characterisation and expression in a teleost fish, Fugu rubripes

Journal of Molecular Endocrinology
M S ClarkP M Ingleton

Abstract

The present report describes the structure and expression of the calcitonin gene in Fugu rubripes. It is composed of 4 exons and 3 introns. Splicing of exons 1, 2 and 3 generates the calcitonin pre-proprotein, while splicing of exons 1, 2 and 4 generates calcitonin gene-related protein (CGRP). Exons 1 and 2 encoding the signal sequence and the N-terminal peptide are common in both the gene products and this gene organisation has been conserved in human, rat, chicken and salmon. The gene environment around calcitonin in Fugu has been poorly conserved when compared with human, apart from a small gene cluster. The calcitonin gene in Fugu has a widespread tissue distribution but it is most highly expressed in the brain. The abundance of gene expression in the ultimobranchial gland and the pituitary indicates that these are important sites of production and that the peptide is probably secreted into the circulation and/or acts as a paracrine or autocrine controlling factor. Whilst the function of calcitonin in fish is still largely unknown, the distribution described here suggests that one of the potential functions may be as a neuropeptide.

Citations

Nov 10, 2006·Cell and Tissue Research·Sreenivasa R MaddineniRamesh Ramachandran
Jan 1, 2011·Journal of Basic and Clinical Physiology and Pharmacology·Ajai Kumar SrivastavSunil Kumar Srivastav
May 13, 2014·General and Comparative Endocrinology·Rute MartinsDeborah M Power
Aug 16, 2008·Journal of Insect Physiology·Jelena PuraćMelody S Clark
Aug 4, 2007·General and Comparative Endocrinology·Kakon NagShigehisa Hirose
Apr 7, 2007·General and Comparative Endocrinology·Masakazu SuzukiShigeyasu Tanaka
May 9, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Burkhard AltKlaus B Rohr
May 11, 2012·The Journal of Experimental Biology·Jean-Claude Le MévelJ Michael Conlon

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