Calcitonin gene-related peptide affords gastric mucosal protection by activating potassium channel in Wistar rat

Gastroenterology
K DoiM Fujishima

Abstract

Calcitonin gene-related peptide (CGRP) protects the gastric mucosa against injurious stimuli in various experimental models. The underlying mechanism could be the increase in gastric mucosal blood flow (GMBF). A number of endogenous vasodilators exert their effects through the activation of adenosine triphosphate (ATP)-sensitive potassium (KATP) channels on vascular smooth muscle. The present experiments were performed to elucidate whether CGRP increases GMBF through the activation of KATP channels and whether the channels are involved in the protection by CGRP of gastric mucosa. GMBF was determined by the hydrogen-clearance technique in male Wistar rats. Mucosal lesions were produced by intragastric superfusion with 0.15N HCland 15% ethanol for 40 minutes. Effects of an agonist (Y-26763, intra-arterially) and an inhibitor (glibenclamide, intravenously) of KATP channels were tested. Y-26763 increased GMBF, which was abolished by glibenclamide, and a CGRP-induced increase in GMBF was attenuated by glibenclamide. Macroscopic and microscopic lesions were exacerbated by human CGRP-(8-37) (a CGRP-1 receptor antagonist; intra-arterially) and glibenclamide but were ameliorated by exogenous CGRP (intra-arterially). CGRP protects the ga...Continue Reading

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Citations

Jun 27, 2002·Peptides·Kousaku KawashimaYoshikazu Kinoshita
Apr 20, 2006·Critical Reviews in Food Science and Nutrition·M N Satyanarayana
Sep 10, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H G CheonB H Lee
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Brigitta M PeskarBernhard A Peskar
Nov 24, 1999·Scandinavian Journal of Gastroenterology·H P ToroudiB Djahanguiri
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·T IchikawaK Hotta
Nov 16, 2021·Cellular and Molecular Life Sciences : CMLS·Zilin DengXuemei Liu

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