Calcitonin gene-related peptide and reperfusion injury

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
D M AllenJ R Urbaniak

Abstract

Calcitonin gene-related peptide is a potent intrinsic vasodilator, can induce prostacyclin release, and may inhibit membrane lipid peroxidation. This study examines the effect of calcitonin gene-related peptide on vessel diameters, capillary perfusion, and contractile function of skeletal muscle after 4 or 5 hours of ischemia and during immediate reperfusion using the rat cremaster muscle model. Forty-two male rats were used; half of these received 0.2 ml of 10(-7) M calcitonin gene-related peptide after 0, 15, and 30 minutes of reperfusion, while the other half received normal saline as a control. By means of intravital videomicroscopy, the diameters of 10 vessels per muscle were measured prior to ischemia and during reperfusion. The fluorescein filling area was determined at 15, 30, and 60 minutes of reperfusion. After 1 hour of reperfusion, muscle function was examined in vitro by quantifying the contractile response to electric field stimulation of the muscles in an organ bath system. There was a significant increase in the diameter of the arterioles, but not the small arteries, at every time point from 10 to 60 minutes of reperfusion. The fluorescein filling area was increased in treated muscles at every time point. Contra...Continue Reading

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Citations

Jul 10, 2012·Journal of Physiology and Biochemistry·You Bing YangInho Hwang
Feb 11, 2003·Obstetrics and Gynecology·Béla Endre ReschGeorge Falkay
Jul 27, 2006·Acta Pharmacologica Sinica·Hong-Gang WangXiao-Lin Liu
Mar 26, 2014·Cephalalgia : an International Journal of Headache·Marcelo E BigalRafael Escandon
Oct 13, 2018·CNS Drugs·Marcelo E BigalErnesto Aycardi
May 8, 2019·Biological & Pharmaceutical Bulletin·Florencia MussoLorena Milanesi
May 3, 2019·Expert Review of Neurotherapeutics·Marcelo E BigalAlan M Rapoport

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