Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine

British Journal of Pharmacology
S D Brain

Abstract

The neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator that is contained in and released from sensory nerves. CGRP has been implicated in migraine, and the nonpeptide CGRP antagonist BIBN4096BS has been shown to be effective in clinical trials in migraine. To date, it has been largely assumed that the CGRP antagonist is effective due to its ability to block vasodilator activity. Goadsby and co-workers present data that now suggest that CGRP antagonists may also block neuronal transmission in migraine.

References

Jan 3, 1985·Nature·S D BrainI MacIntyre
Mar 11, 2000·British Journal of Pharmacology·H DoodsW Eberlein
Jan 25, 2002·The New England Journal of Medicine·Peter J GoadsbyMichel D Ferrari
Jun 5, 2003·Expert Opinion on Therapeutic Targets·Lars Edvinsson
Mar 12, 2004·The New England Journal of Medicine·Jes OlesenUNKNOWN BIBN 4096 BS Clinical Proof of Concept Study Group

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Citations

Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alessandro TozziPaolo Calabresi
Jan 30, 2009·Headache·Richard J HargreavesFred D Sheftell
Feb 5, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jasna Zidverc-TrajkovicLjiljana Jankovic
Apr 12, 2007·Headache·Richard Hargreaves
Sep 8, 2009·Journal of Neuroimmunology·María Guadalupe Reyes-García, Fernando García-Tamayo
Nov 12, 2009·Expert Review of Neurotherapeutics·Vinod Kumar Gupta
Apr 5, 2017·Frontiers in Neurology·Charles Stevens Leger, Joseph F X DeSouza

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