PMID: 9533648Apr 9, 1998Paper

Calcitonin gene-related peptide (CGRP), but not tachykinins, causes relaxation of small arteries from the rainbow trout gut

Peptides
J Kågström, S Holmgren

Abstract

Possible vasoactive effects on small diameter arteries from the rainbow trout gut of calcitonin gene-related peptide (CGRP-chicken) and different fish tachykinins; substance P (SP-trout), neurokinin A (NKA-trout), scyliorhinin I and II (SCY I and SCY II-dogfish), were investigated. CGRP relaxed precontracted arteries with a pD2 value of 8.3+/-0.2. Relaxation to CGRP 10(-8) M was reduced by 86.4+/-5.2% by the CGRP-1 receptor antagonist CGRP8-37 (10(-6) M), but unaffected by NG-nitro-L-arginine (10(-4) M), indomethacin (10(-6) M) and by removal of the endothelium, suggesting no involvement of nitric oxide, prostaglandins or endothelium-derived factors. A low number of CGRP immunoreactive fibers were present in the arterial wall. The tachykinins (10(-12)-10(-6) M) occasionally contracted the relaxed vessel. No synergistic action of SP on the CGRP-induced response was found. A dense plexus of tachykinin-containing fibers without coexisting CGRP innervated the arterial wall. Tachykinins or CGRP had no effect on small diameter veins, and no such immunoreactivity was found in these vessels. In conclusion, CGRP- and tachykinin-containing fibers innervate trout gut arteries. CGRP probably is vasodilatory, while the function of the tachy...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·T Tsuji, D A Cook
Jan 1, 1992·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J Jensen, S Holmgren
Jun 30, 1992·Annals of the New York Academy of Sciences·H S Jansz, J Zandberg
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Jan 1, 1990·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J A DonaldH B Lillywhite
Nov 12, 1991·European Journal of Pharmacology·P D'Orléans-JusteD Regoli
Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Oct 30, 1990·Biochemical and Biophysical Research Communications·M Fouchereau-PeronM S Moukhtar
May 5, 1986·FEBS Letters·J M ConlonL Thim
Aug 1, 1987·British Journal of Pharmacology·G C GraceT J Martin
Oct 1, 1988·General and Comparative Endocrinology·L W KlineP K Pang
Jan 3, 1985·Nature·S D BrainI MacIntyre
Apr 1, 1994·Journal of Cardiovascular Pharmacology·L E GustafssonY Elias
Feb 1, 1993·Journal of Cardiovascular Pharmacology·T MatsumotoN Toda
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·W I RosenblumG H Nelson
Jan 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P D'Orléans-JusteG E Plante
Jan 1, 1997·The American Journal of Physiology·H C ChampionP J Kadowitz

❮ Previous
Next ❯

Citations

Mar 8, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Brett L JenningsJohn A Donald
Oct 7, 2008·Fish Physiology and Biochemistry·Fatemeh ShahbaziJörgen Jensen
Feb 11, 2000·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·K H Wrobel, M N Moustafa
Mar 9, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryan A DombkowskiKenneth R Olson
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fatemeh ShahbaziJörgen Jensen
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N MimassiJ C Le Mével
Dec 18, 2018·Frontiers in Endocrinology·Toshio Sekiguchi
Dec 4, 2020·Physiological Reviews·Christian AalkjærJo G R De Mey
May 11, 2012·The Journal of Experimental Biology·Jean-Claude Le MévelJ Michael Conlon
Aug 25, 2004·The Journal of Experimental Biology·Peter Vilhelm Skov, Michael Brian Bennett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.