Calcitonin gene-related peptide, heme oxygenase-1, endothelial progenitor cells and nitric oxide-dependent vasodilation relationships in a human model of angiotensin II type-1 receptor antagonism

Journal of Hypertension
Lorenzo A CalòGian Paolo Rossi

Abstract

An increased number of endothelial progenitor cells (EPCs), which correlated with heme oxygenase-1 gene expression and nitric oxide-mediated vasodilation [flow-mediated dilation (FMD)], has been recently reported by us in Bartter/Gitelman syndromes, rare diseases that represent a human model of endogenous angiotensin (Ang) II type-1 receptor antagonism and depicting an opposite picture of hypertension. Calcitonin gene-related peptide (CGRP), which prevents circulating EPCs senescence and reverses Ang II-induced EPCs senescence is reduced in hypertensive patients, its level is stimulated by heme oxygenase-1 and is related with stimulation of nitric oxide. This study reports on CGRP concentration and heme oxygenase-1 protein level in Bartter/Gitelman syndrome's patients compared with healthy individuals and analyzes their relationships with EPCs [CD34⁺kinase insert domain receptor (KDR⁺), CD133⁺KDR⁺, CD34⁺CD133⁺KDR⁺) as well as FMD. CGRP concentration (ELISA) and heme oxygenase-1 protein level (sandwich immunoassay) were higher in Bartter/Gitelman syndrome : 38.20 ± 8.23 pg/ml vs. 25.07 ± 3.51, P < 0.002 and 9.44 ± 3.1 ng/ml vs. 5.52 ± 1.1, P < 0.007, respectively. CD133⁺KDR⁺ and CD34⁺CD133⁺KDR⁺ (direct three-color flow cytometry...Continue Reading

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Citations

May 24, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Paul A DavisLorenzo A Calò
Oct 30, 2013·Clinical and Experimental Hypertension : CHE·Inez ReevesRichard M Millis
Apr 18, 2014·European Journal of Clinical Investigation·Lorenzo A CalòPaul A Davis
Mar 14, 2014·International Journal of Vascular Medicine·Maria SambataroAngelo Paolo Dei Tos
Dec 21, 2013·Journal of Hypertension·Lorenzo A CalòGian Paolo Rossi

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