[Calcitonin gene-related peptide immunoreactive nerve fibres in the dura mater encephali of the rat: experiments related to the neurogenic inflammation of meningeal structures.].

Der Schmerz
K Meßlinger, U Hanesch

Abstract

In this paper morphological and physiological experiments are described that refer to the concept of neurogenic inflammation of meningeal structures as a putative source of migrainous pain and other headaches. The main emphasis of this study carried out on the duramater encephali of the rat was the functional role of calcitonin generelated peptide (CGRP), a vasodilatory neuropeptide of fine afferent nerve fibres. Immunocytochemical preparations showed that the parietal dura mater was densely innervated by CGRP immunoreactive nerve fibres, the distribution and ultrastructure of which were examined by ligh and electron microscopy. The dense innervation around the medial meningeal artery suggested a vasomotor function of these peptidergic fibres. In further experiments the CGRP immune product of the nerve fibres could be diminished by electrical stimulation of the dura mater. Extracellular recordings from trigeminal ganglion cells showed that electrical and mechanical stimulation of large dural vessels activate trigeminal afferents. In a final series of experiments the dural blood flow around branches of the medial meningeal artery was measured with a laser Doppler flowmeter. The blood flow was increased by electrical stimulation ...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Jul 1, 1979·Acta Physiologica Scandinavica·A BillG Nilsson
Feb 26, 1990·Brain Research·P GeppettiF Sicuteri
May 1, 1991·British Journal of Pharmacology·F Y Lam, W R Ferrell
Jul 22, 1991·The Journal of Comparative Neurology·J T Keller, C F Marfurt
Feb 1, 1991·Headache·J E Hardebo
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J McCullochL Edvinsson
Jan 3, 1985·Nature·S D BrainI MacIntyre
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·N JancsóJ Szolcsányi
Aug 1, 1984·Annals of Neurology·M A Moskowitz
Jan 1, 1981·Annual Review of Medicine·N H Raskin
Jan 1, 1983·Annals of Neurology·P D Drummond, J W Lance

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Citations

May 21, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·V Pudel, T Ellrott
Oct 29, 2013·Annual Review of Entomology·Keram Pfeiffer, Uwe Homberg

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