Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects.

Journal of Neurology, Neurosurgery, and Psychiatry
Jason Charles RayElspeth Jane Hutton


Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes of therapeutics have been specifically developed to combat migraine. After 30 years of translational research, calcitonin gene-related peptide (CGRP) inhibitors have emerged as a promising new tool in the prevention of migraine. Like all new therapeutics; however, we have limited real-world experience and CGRP has several known systemic actions that warrant consideration. This article provides a narrative review of the evidence for CGRP antagonists and summarises the known and potential side effects that should be considered.


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Oct 10, 2021·The Journal of Headache and Pain·Jason C RayElspeth J Hutton

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