Calcitonin gene related peptide in migraine: current therapeutics, future implications and potential off-target effects.

Journal of Neurology, Neurosurgery, and Psychiatry
Jason Charles RayElspeth Jane Hutton

Abstract

Migraine is the second largest cause of years lost to disability globally among all diseases, with a worldwide prevalence over 1 billion. Despite the global burden of migraine, few classes of therapeutics have been specifically developed to combat migraine. After 30 years of translational research, calcitonin gene-related peptide (CGRP) inhibitors have emerged as a promising new tool in the prevention of migraine. Like all new therapeutics; however, we have limited real-world experience and CGRP has several known systemic actions that warrant consideration. This article provides a narrative review of the evidence for CGRP antagonists and summarises the known and potential side effects that should be considered.

References

Jan 1, 1992·Pharmacology & Therapeutics·D R Poyner
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L EdvinssonR Uddman
Jan 3, 1985·Nature·S D BrainI MacIntyre
Jul 1, 1995·Nature Medicine·C WeillerH C Diener
Sep 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Z Khalil, R Helme
Feb 5, 1998·Annals of Neurology·F M CutrerM A Moskowitz
Apr 29, 1998·European Journal of Pharmacology·A Argiolas, M R Melis
Dec 20, 2000·The Journal of Investigative Dermatology·C WeidnerM Schmelz
Jun 14, 2003·TheScientificWorldJournal·Lars Edvinsson
Apr 19, 2005·Headache·Richard B Lipton, Marcelo E Bigal
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jun 2, 2005·Hypertension·Mark C BowersScott C Supowit
Mar 27, 2007·Cephalalgia : an International Journal of Headache·P J GoadsbyB Parsons
Sep 22, 2010·Cephalalgia : an International Journal of Headache·Jakob Møller HansenMessoud Ashina
Jan 29, 2011·Neuropeptides·Sarah-Jane Smillie, Susan D Brain
Jan 27, 2012·Clinical Pharmacology and Therapeutics·B R ChaitmanR L Blanchard
May 16, 2013·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H TanakaT Koizumi
May 17, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claude RobertLuis Villanueva
Jun 12, 2013·Current Protein & Peptide Science·Bernhard Holzmann
Aug 27, 2013·The American Journal of Cardiology·Gamze AslanHaldun Muderrisoglu
Mar 5, 2014·Frontiers in Neuroscience·Bakri M AssasJaleel A Miyan
Aug 1, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne E LuebkeKathleen E Cullen
Aug 29, 2014·Cephalalgia : an International Journal of Headache·Zsolt HeppEmily B Devine
Sep 11, 2014·Kidney International·Jinu Kim, Babu J Padanilam
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
Jun 25, 2016·Trends in Pharmacological Sciences·Antoinette MaassenVanDenBrinkMichel D Ferrari
Feb 10, 2017·Physiological Reviews·Peter J GoadsbySimon Akerman
May 12, 2017·JAMA : the Journal of the American Medical Association·Nicholas S DowningJoseph S Ross

❮ Previous
Next ❯

Citations

Oct 10, 2021·The Journal of Headache and Pain·Jason C RayElspeth J Hutton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Neurology
Nazia Karsan, Peter J Goadsby
Cephalalgia : an International Journal of Headache
Jes Olesen
The Journal of Headache and Pain
Peer Tfelt-Hansen, Messoud Ashina
Journal of Neurology
M Cauchi, N P Robertson
Cephalalgia : an International Journal of Headache
Jes Olesen
© 2022 Meta ULC. All rights reserved