PMID: 8957381Dec 1, 1996Paper

Calcitonin gene-related peptide-induced preconditioning improves preservation with cardioplegia

The Annals of Thoracic Surgery
E LuS X Cheng

Abstract

Our recent work has shown that calcitonin gene-related peptide (CGRP) may play an important role in mediation of ischemic preconditioning. Therefore, we tested the hypothesis that CGRP-induced preconditioning protects against myocardial damage after prolonged cardioplegic arrest in isolated rat hearts. Six groups were studied: the control, ischemic preconditioning, and CGRP-pretreated groups for both 4- and 8-hour hypothermic ischemia. All hearts were arrested using St. Thomas Hospital cardioplegia, and then reperfused with normothermic Krebs-Henseleit solution for 60 minutes after the 4- or 8-hour hypothermic ischemic period. Hearts were subjected to two cycles of 5-minute ischemia and 10-minute reperfusion in the ischemic preconditioning group. In the CGRP-pretreated group, Krebs-Henseleit solution containing CGRP (5 x 10(-9) mol/L) was substituted for the ischemic period. At 30 minutes of reperfusion after 4-hour storage, left ventricular pressure (mm Hg) and its first derivative (dp/dtmax, mm Hg/s) in the control, ischemic preconditioning, and CGRP groups were 65.2 +/- 5.93 and 1,170 +/- 119, 94.13 +/- 4.93 and 1,825 +/- 145.83, and 85.47 +/- 4.17 and 1,900 +/- 123.13, respectively (p < 0.01). After 8-hour storage, left ven...Continue Reading

References

Feb 1, 1995·The Annals of Thoracic Surgery·D T EngelmanR M Engelman
Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A M AlkhulaifiW B Pugsley

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Citations

Jun 18, 2002·European Journal of Pharmacology·Yuan-Jian Li, Jun Peng
Sep 26, 1997·The Journal of Thoracic and Cardiovascular Surgery·E X LuX Guo
Jul 1, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·G LiY Li

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