PMID: 8470332Apr 1, 1993Paper

Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys

Urology
C G StiefE A Tanagho

Abstract

The distribution of calcitonin gene-related peptide (CGRP) immunoreactivity in the cavernous tissue and the erectile response to intracavernous injection of CGRP was investigated in 7 monkeys. Intracavernous CGRP increased cavernous arterial flow and induced cavernous smooth muscle relaxation and venous outflow occlusion. Intracavernous injection of CGRP antibody did not significantly change the erectile response to cavernous nerve stimulation. Histologic staining for CGRP immunoreactivity showed nerve fiber-like staining within the cavernous arterial wall and the cavernous smooth muscles. These data suggest that CGRP may contribute to penile erection in monkeys.

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Citations

Jan 1, 1997·World Journal of Urology·M C TrussU Jonas
Sep 17, 2011·Current Urology Reports·Eric Chung, Gerald B Brock
Jan 14, 1997·European Journal of Pharmacology·H C ChampionP J Kadowitz
May 1, 1996·British Journal of Pharmacology·J Y ChanS H Chan
Feb 3, 2005·Asian Journal of Andrology·Zhou-Jun ShenZhao-Dian Chen
Feb 17, 2010·Nature Reviews. Urology·Ahmed HarrazTom F Lue
Jan 21, 2009·Autonomic Neuroscience : Basic & Clinical·J F B MorrisonF C Howarth
Jun 3, 2000·Nitric Oxide : Biology and Chemistry·T J BivalacquaW J Hellstrom
Oct 24, 2001·Biology of Reproduction·T J BivalacquaW J Hellstrom
Mar 22, 2008·Health & Social Care in the Community·Viet Nguyen-GillhamWill Boyce
Aug 19, 2021·Cephalalgia : an International Journal of Headache·Linda Al-HassanyAntoinette MaassenVanDenBrink

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