Immunoreactive calcitonin (CT), indistinguishable from human CT-(1-32) and its sulfoxide, has been identified in extracts of the hypothalamus, the pituitary, and the thyroid obtained from human subjects at autopsy. DCT concentrations were highest in a region encompassing the posterior hypothalamus, the median eminence, and the pituitary; intermediate in the substantia nigra, the anterior hypothalamus, the globus pallidus, and the inferior colliculus; and low in the caudate nucleus, the hippocampus, the amygdala, and the cerebral and cerebellar cortices. Specific CT binding measured with 125I-labeled salmon CT was highest in homogenates of the posterior hypothalamus and the median eminence, shown to contain the highest concentrations of endogenous CT in the brain; CT binding was less than 12% of hypothalamic binding in all of the other regions of the brain examined and was negligible in the pituitary. Half-maximal binding was achieved with 0.1 nM nonradioactive salmon CT-(1-32), and the binding was directed to structural or conformational sites, or both, in the COOH-terminal half of salmon CT. The rank order of the inhibition of the binding by CT from different species and analogues of the human hormone was the same as in recept...Continue Reading
Effects of guanyl nucleotides on calcitonin-sensitive adenylate cyclase and calcitonin binding in rat renal cortex
Localization of somatostatin-, substance P- and calcitonin-like immunoreactivity in the neural ganglion of Ciona intestinalis L. (Ascidiaceae)
Demonstration by immunoperoxidase histochemistry of calcitonin in the anterior lobe of the rat pituitary
Elevation of calcitonin immunoreactivity in the pituitary and thyroid glands of genetically obese rats (fa/fa)
Synthetic human calcitonin: analysis of antibodies obtained from various animal species and determination of immunoreactive hormone in human sera
Concentrations of calcitonin and catecholamines in pheochromocytomas, a mucosal neuroma and medullary thyroid carcinoma
Specific binding of 125I-salmon calcitonin to rat brain: regional variation and calcitonin specificity
Calcitonin-like immunoreactivity in rat and human pituitary glands: histochemical, in vitro, and in vivo studies
Adenylate cyclase activation and competitive binding with renal tissue using synthetic eel calcitonin analog and its fragments
Immunoreactive human calcitonin-like molecule in the nervous systems of protochordates and a cyclostome, Myxine
Calcitonin inhibits testosterone and luteinizing hormone secretion through a mechanism involving an increase in cAMP production in rats
Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids
Immunoreactive "calcitonin-like" material in heroin addicts: varying reactivity with different antibodies
Increase of pain threshold by calcitonin during electrical stimulation of the dental pulp. Investigations in healthy volunteers with regard to plasma concentration.
A synthetic peptide derived from mouse pituitary calcitonin cDNA sequence exhibits potent inhibition of prolactin secretion and prolactin mRNA abundance in primary mouse pituitary cells.
Localization of calcitonin binding sites in rat central nervous system: evidence of its neuroactivity
Calcitonin receptors in the rat mesencephalon mediate its analgesic actions: autoradiographic and behavioral analyses
Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-D-aspartate-induced aversive behavior
Calcitonin binding site distribution in the cat central nervous system: a wider insight of the peptide involvement in brain functions
Identity of calcitonin extracted from normal human thyroid glands with synthetic human calcitonin-(1-32)
Calcitonin gene-related peptide in medullary thyroid carcinomas: characterization of molecular forms including the amidated C-terminus
Evidence for a new subclass of calcitonin/ calcitonin gene-related peptide binding site in rat brain
Evidence for different classes of calcitonin binding sites in rat CNS: an autoradiographic study with carbo-calcitonin
Antinociceptive activity of salmon calcitonin: electrophysiological correlates in a rat chronic pain model
Biodistribution of calcitonin encapsulated in liposomes in mice with particular reference to the central nervous system
Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiography
Effects of cerebral lesions on binding sites for calcitonin and calcitonin gene-related peptide in the rat nucleus accumbens and ventral tegmental area
The influence of phospholipid membranes on bovine calcitonin peptide's secondary structure and induced neurotoxic effects
Ovariectomy-induced hyperalgesia and antinociceptive effect of elcatonin, a synthetic eel calcitonin
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