Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease

Journal of Veterinary Internal Medicine
D H N van den BroekR E Jepson

Abstract

Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats. To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of plasma calcitonin with ionized calcium, alkaline phosphatase (ALP), and urinary calcium excretion. Thirty-three client-owned cats with azotemic CKD and ionized hypercalcemia from first opinion practice. Cohort study. Calcitonin was measured with an immunoradiometric assay in heparinized plasma. Simple correlations were assessed with Kendall's rank correlation, and the within-subject correlations of calcitonin with ionized calcium and other clinicopathological variables were calculated with a bivariate linear mixed effects model. Calcitonin concentrations above the lower limit of detection (>1.2 pg/mL; range, 1.7-87.2 pg/mL) were observed in 11 of 33 hypercalcemic cats (responders). Blood ionized calcium concentration did not differ significantly between responders (median, 1.59 [1.46, 1.66] mmol/L) and nonresponders (median, 1.48 [1.43, 1.65] mmol/L; P = 0.22). No evidence was found for calcitonin and ionized calcium to correlate between cats (τb  = 0.14; P = 0.31; n = 33), but significant positive correlation ...Continue Reading

References

Jan 1, 1977·Nephron·O L SilvaC F Moore
Nov 1, 1977·The Journal of Clinical Investigation·H Heath, G W Sizemore
Apr 19, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A G Pearse
Jan 17, 1970·British Medical Journal·M CochranB E Nordin
Oct 1, 1983·The Journal of Clinical Endocrinology and Metabolism·T J Chambers, A Moore
Apr 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R FarleyJ E Wergedal
Dec 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P MessaU P Guerra
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C Monier-FaugereH H Malluche
Apr 29, 1998·The Journal of Small Animal Practice·P J Barber, J Elliott
Mar 24, 1999·The Journal of Small Animal Practice·P J BarberJ Elliott
Apr 20, 2000·Journal of Veterinary Internal Medicine·K C SavaryS L Vaden
May 23, 2002·Veterinary Clinical Pathology·Anne Provencher BolligerKent R Refsal
Jan 1, 1995·Veterinary Clinical Pathology·Thomas J. RosolCharles C. Capen
Apr 24, 2003·Journal of the Air & Waste Management Association·Anthony HamlettRuss Wolfinger
Sep 30, 2003·Endocrine·Philip F Hirsch, Hans Baruch
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Melita M DvorakDaniela Riccardi
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kyra A BorchhardtGere Sunder-Plassmann
Apr 26, 2006·Veterinary Surgery : VS·Elaine C NaanMarijke E Peeters
Dec 7, 2007·European Journal of Endocrinology·Michèle d'HerbomezUNKNOWN French Group GTE (Groupe des Tumeurs Endocrines)
Jan 13, 2009·Domestic Animal Endocrinology·K M RourkeR E Toribio
Apr 14, 2009·Clinical Biochemistry·Jacques P BrownLouis-Georges Ste-Marie
Nov 1, 1945·Biometrika·M G KENDALL
Nov 2, 2012·Journal of the American Veterinary Medical Association·Natalie C FinchJonathan Elliott
Feb 13, 2013·Journal of Veterinary Internal Medicine·R F GeddesH M Syme
Mar 23, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rachel A Davey, David M Findlay
Nov 28, 2013·American Journal of Veterinary Research·Carmen PinedaIgnacio Lopez
Oct 8, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Judith BlaineMoshe Levi
Mar 31, 2015·Clinical Kidney Journal·Arnold J Felsenfeld, Barton S Levine
Apr 29, 2015·Journal of Veterinary Internal Medicine·E S BijsmansJ Elliott
May 5, 2016·Journal of Feline Medicine and Surgery·Natalie C Finch
Feb 13, 2017·Journal of Veterinary Internal Medicine·D H N van den BroekR E Jepson

❮ Previous
Next ❯

Citations

May 7, 2021·JFMS Open Reports·Carolina Sc AlbuquerqueDanièlle A Gunn-Moore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.