Calcitonin-secreting tumor of the pancreas

Digestive Surgery
Prashant M MullerpatanIrvin Modlin

Abstract

Pancreatic endocrine tumors (PETs) are unusual tumors arising from cells belonging generically to the amine precursor uptake and decarboxylation systems. We present a case of a calcitonin-secreting PET in a 56-year-old female who presented with watery diarrhea, dehydration and hypokalemia. Investigation revealed hypercalcemia, hyperphosphatemia, hypercalcitonemia and a well-defined mass in the head of the pancreas on CT scan. Following a pancreaticoduodenectomy her serum calcitonin levels returned to normal and diarrhea disappeared. The identification of this particularly rare presentation of a calcitonin-secreting PET provides the opportunity to examine this pathological entity within the context of the very few previously reported instances of this disease.

Citations

Aug 25, 2012·Gastroenterology Clinics of North America·Elisabeth FabianGuenter J Krejs
Dec 21, 2010·Seminars in Oncology·Kjell Oberg
Sep 8, 2010·Annales d'endocrinologie·C Do CaoJ-L Wémeau
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Rossella Elisei
Jan 22, 2011·Journal of Cellular and Molecular Medicine·Hongguang LiuPradeep K Dudeja
Aug 9, 2006·European Journal of Gastroenterology & Hepatology·Laurent WuilmetGuillaume Cadiot
May 6, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Martina KováčováUtpal B Pajvani

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