Calcitonin, the forgotten hormone: does it deserve to be forgotten?

Clinical Kidney Journal
Arnold J Felsenfeld, Barton S Levine

Abstract

Calcitonin is a 32 amino acid hormone secreted by the C-cells of the thyroid gland. Calcitonin has been preserved during the transition from ocean-based life to land dwellers and is phylogenetically older than parathyroid hormone. Calcitonin secretion is stimulated by increases in the serum calcium concentration and calcitonin protects against the development of hypercalcemia. Calcitonin is also stimulated by gastrointestinal hormones such as gastrin. This has led to the unproven hypothesis that postprandial calcitonin stimulation could play a role in the deposition of calcium and phosphate in bone after feeding. However, no bone or other abnormalities have been described in states of calcitonin deficiency or excess except for diarrhea in a few patients with medullary thyroid carcinoma. Calcitonin is known to stimulate renal 1,25 (OH)2 vitamin D (1,25D) production at a site in the proximal tubule different from parathyroid hormone and hypophosphatemia. During pregnancy and lactation, both calcitonin and 1,25D are increased. The increases in calcitonin and 1,25D may be important in the transfer of maternal calcium to the fetus/infant and in the prevention and recovery of maternal bone loss. Calcitonin has an immediate effect on ...Continue Reading

References

Oct 13, 1979·Lancet·J C StevensonM I Whitehead
Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J G Parthemore, L J Deftos
Jan 1, 1977·Nephron·O L SilvaC F Moore
Feb 1, 1979·The Journal of Clinical Investigation·R KumarF H Epstein
Aug 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J G Parthemore, L J Deftos
Nov 1, 1977·The Journal of Clinical Investigation·H Heath, G W Sizemore
Mar 11, 1992·Bone and Mineral·J T Potts
Oct 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T Naveh-ManyJ Silver
Mar 1, 1992·Bone and Mineral·D H Copp
Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·D T Baran, L E Braverman
May 1, 1989·Molecular and Cellular Endocrinology·H ScherüblR Ziegler
Apr 1, 1988·The American Journal of Physiology·R E SimmonsR Rabkin
Jan 1, 1988·The Journal of Clinical Investigation·T Naveh-Many, J Silver
Aug 1, 1986·The Journal of Clinical Investigation·G C NicholsonT J Martin
Jun 1, 1988·European Journal of Clinical Investigation·F RaueR Ziegler
Aug 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D TiegsH Heath
Sep 1, 1986·The Journal of Clinical Endocrinology and Metabolism·R D TiegsH Heath
Apr 19, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A G Pearse
Dec 1, 1973·The Journal of Clinical Investigation·L J DeftosJ T Potts
Jan 1, 1973·Nephron·B G DelanoS Wallach
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·H D NiallJ T Potts
Apr 1, 1984·Kidney International·J A KrautK Kurokawa
Oct 1, 1983·The Journal of Clinical Endocrinology and Metabolism·T J Chambers, A Moore
Jul 15, 1982·The Biochemical Journal·H C Freake, I MacIntyre
Dec 1, 1984·Calcified Tissue International·G L KleinL J Deftos
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R V TalmageC J Vanderwiel
Jan 1, 1982·Clinical Endocrinology·T CundyC G Woods
Aug 1, 1982·Clinical Science·J A KanisR G Russell
Apr 1, 1980·The Journal of Clinical Investigation·D E CareyL J Deftos
Jun 12, 1980·The New England Journal of Medicine·L J DeftosH L Judd
Sep 16, 1993·The New England Journal of Medicine·A MitrakouP Cryer
Mar 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A J FelsenfeldM Rodriguez
Dec 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P MessaU P Guerra
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C Monier-FaugereH H Malluche
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D PienkowskiH H Malluche
Nov 24, 1999·The Journal of Clinical Investigation·L I PlotkinT Bellido

❮ Previous
Next ❯

Citations

May 23, 2016·Transgenic Research·Maarit S PatrikainenSeppo Parkkila
Feb 23, 2018·Journal of Veterinary Internal Medicine·D H N van den BroekR E Jepson
Jan 11, 2019·PloS One·Haya AlomaimJesse Bertinato
May 30, 2019·International Journal of Molecular Sciences·Sabrina EhnertAndreas K Nussler
May 30, 2019·International Journal of Molecular Sciences·Yuichiro UkonTakashi Kaito
Nov 9, 2019·Current Protein & Peptide Science·Sridhar MuthusamiNagarajan Selvamurugan
May 19, 2020·EMBO Reports·Hans-Willem Snoeck
Feb 26, 2019·Frontiers in Cardiovascular Medicine·Grzegorz B WasilewskiLeon J Schurgers
Dec 14, 2018·Scientific Reports·Joana MarquesHenrique Silveira
Nov 28, 2019·Journal of Medicinal Chemistry·Joseph ChabenneRichard D DiMarchi
Feb 23, 2021·Molecular Therapy Oncolytics·Vijay G BhojDon L Siegel
Sep 21, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Felix EckeltJuergen Kratzsch

❮ Previous
Next ❯

Methods Mentioned

BETA
gene knockout

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zeitschrift für ärztliche Fortbildung
W Meng
Current Topics in Experimental Endocrinology
I MacIntyre
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
M FrölichC W Thesingh
© 2021 Meta ULC. All rights reserved